@inproceedings{c476829e8004432986e6e70539fa513a,
title = "Simultaneous topography and RECognition mapping with PicoTREC{\texttrademark}: A powerful new technology that can be used to map nanometer-scale molecular binding sites on a variety of surfaces",
abstract = "PicoTREC{\texttrademark} is a powerful new chemical/biological detection technology that combines nanoscale Topographic imaging the AFM with single molecule RECognition mapping. The technique has been used to map interactions between, for example charged species, antibodies/antigens, and ligands/receptors in order to analyze the chemical composition of a variety of samples. PicoTREC combines in-situ nanometer scale, resolution imaging with the selectivity and sensitivity of single molecule, piconewton sensitivity to resolve and detect recognition events. It is label-less, so it is not dependent on fluorescence, radioactivity, or enzyme-linked detection schemes. When a ligand for a particular receptor is attached to an AFM tip, the AFM tip becomes a chemically selective sensor so that the forces required to break chemical bonds with the specific binding epitopes on target molecules can be detected and resolved. Consequently, maps of binding sites across a variety surfaces can quickly and easily be obtained.",
keywords = "AFM, Antibody-antigen, Biosensor, Ligand-receptor, Nanobiotechnology",
author = "Johnson, {W. T.} and G. Kada and C. Stroh and H. Gruber and H. Wang and F. Kienberger and A. Ebner and Stuart Lindsay and P. Hinterdorfer",
year = "2005",
language = "English (US)",
isbn = "0976798514",
series = "2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings",
pages = "679--682",
editor = "M. Laudon and B. Romanowicz",
booktitle = "2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings",
note = "2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 ; Conference date: 08-05-2005 Through 12-05-2005",
}