Simulation of diabetic retinopathy neovascularization in color digital fundus images

Xinyu Xu, Baoxin Li, Jose F. Florez, Helen K. Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) has been identified as a leading cause of blindness. One type of lesion, neovascularization (NV), indicates that the disease has entered a vision-threatening phase. Early detection of NV is thus clinically significant. Efforts have been devoted to use computer-aided analyses of digital retina images to detect DR. However, developing reliable NV detection algorithms requires large numbers of digital retinal images to test and refine approaches. Computer simulation of NV offers the potential of developing lesion detection algorithms without the need for large image databases of real pathology. In this paper, we propose a systematic approach to simulating NV. Specifically, we propose two algorithms based on fractal models to simulate the main structure of NV and an adaptive color generation method to assign photorealistic pixel values to the structure. Moreover, we develop an interactive system that provides instant visual feedback to support NV simulation guided by an ophthalmologist. This enables us to combine the low level algorithms with high-level human feedback to simulate realistic lesions. Experiments suggest that our method is able to produce simulated NVs that are indistinguishable from real lesions.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages421-433
Number of pages13
Volume4291 LNCS - I
StatePublished - 2006
Event2nd International Symposium on Visual Computing, ISVC 2006 - Lake Tahoe, NV, United States
Duration: Nov 6 2006Nov 8 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4291 LNCS - I
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other2nd International Symposium on Visual Computing, ISVC 2006
CountryUnited States
CityLake Tahoe, NV
Period11/6/0611/8/06

Fingerprint

Diabetic Retinopathy
Color Image
Digital Image
Color
Simulation
Feedback
Fractals
Sensory Feedback
Retina
Interactive Systems
Image Database
Pathology
Blindness
Instant
Computer Simulation
Assign
Fractal
Pixel
Pixels
Databases

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

Cite this

Xu, X., Li, B., Florez, J. F., & Li, H. K. (2006). Simulation of diabetic retinopathy neovascularization in color digital fundus images. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4291 LNCS - I, pp. 421-433). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4291 LNCS - I).

Simulation of diabetic retinopathy neovascularization in color digital fundus images. / Xu, Xinyu; Li, Baoxin; Florez, Jose F.; Li, Helen K.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4291 LNCS - I 2006. p. 421-433 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4291 LNCS - I).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xu, X, Li, B, Florez, JF & Li, HK 2006, Simulation of diabetic retinopathy neovascularization in color digital fundus images. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 4291 LNCS - I, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 4291 LNCS - I, pp. 421-433, 2nd International Symposium on Visual Computing, ISVC 2006, Lake Tahoe, NV, United States, 11/6/06.
Xu X, Li B, Florez JF, Li HK. Simulation of diabetic retinopathy neovascularization in color digital fundus images. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4291 LNCS - I. 2006. p. 421-433. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
Xu, Xinyu ; Li, Baoxin ; Florez, Jose F. ; Li, Helen K. / Simulation of diabetic retinopathy neovascularization in color digital fundus images. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4291 LNCS - I 2006. pp. 421-433 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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