Semaphorins 4A and 4D in chronic inflammatory diseases

Svetlana P. Chapoval; Zahava Vadasz; Andrei Chapoval; Elias Toubi

doi:10.1007/s00011-016-0983-5

Semaphorins 4A and 4D in chronic inflammatory diseases

Svetlana P. Chapoval, Zahava Vadasz, Andrei Chapoval, Elias Toubi

Innovations in Medicine, Center for (IM)

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.

Original language	English (US)
Pages (from-to)	111-117
Number of pages	7
Journal	Inflammation Research
Volume	66
Issue number	2
DOIs	https://doi.org/10.1007/s00011-016-0983-5
State	Published - Feb 1 2017

Keywords

Asthma
Autoimmune diseases
Cancer
Chronic inflammation
Semaphorins

ASJC Scopus subject areas

Immunology
Pharmacology

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10.1007/s00011-016-0983-5

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abstract = "Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.",

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AU - Vadasz, Zahava

AU - Chapoval, Andrei

AU - Toubi, Elias

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AB - Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.

KW - Asthma

KW - Autoimmune diseases

KW - Cancer

KW - Chronic inflammation

KW - Semaphorins

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Semaphorins 4A and 4D in chronic inflammatory diseases

Abstract

Keywords

ASJC Scopus subject areas

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