Semaphorins 4A and 4D in chronic inflammatory diseases

Svetlana P. Chapoval, Zahava Vadasz, Andrei Chapoval, Elias Toubi

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalInflammation Research
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2017

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Chronic Disease
Autoimmune Diseases of the Nervous System
Immunotherapy
Immune System
Inflammation
Antigens
Lung
CD100 antigen
Neoplasms

Keywords

  • Asthma
  • Autoimmune diseases
  • Cancer
  • Chronic inflammation
  • Semaphorins

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Semaphorins 4A and 4D in chronic inflammatory diseases. / Chapoval, Svetlana P.; Vadasz, Zahava; Chapoval, Andrei; Toubi, Elias.

In: Inflammation Research, Vol. 66, No. 2, 01.02.2017, p. 111-117.

Research output: Contribution to journalReview article

Chapoval, Svetlana P. ; Vadasz, Zahava ; Chapoval, Andrei ; Toubi, Elias. / Semaphorins 4A and 4D in chronic inflammatory diseases. In: Inflammation Research. 2017 ; Vol. 66, No. 2. pp. 111-117.
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