Saliva cotinine levels as a function of collection method

Nina G. Schneider, Peyton Jacob, Fredrik Nilsson, Scott Leischow, Neal L. Benowitz, Richard E. Olmstead

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Saliva cotinine is commonly used to estimate nicotine intake but laboratories use different methods of collection. In three small trials, comparisons were made between (1) sugar vs. unstimulated saliva production (n = 29), (2) wax chewing vs. unstimulated production (n = 15) and (3) between two consecutive unstimulated saliva samples (n = 10). Sugar-stimulated saliva cotinine scores were 26% below unstimulated levels (p < 0.001); correlation between measures was high (r= 0.90; p < 0.001). Wax stimulated saliva yielded levels 6% below unstimulated (p < 0.05; correlation: r= 0.98; p < 0.001). No differences were observed between two unstimulated samples taken within a ~ 20-minute period (correlation: r=0.99;p < 0.001). It is postulated that changes in salivary flow can account for the findings.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalAddiction
Volume92
Issue number3
DOIs
StatePublished - Apr 11 1997

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Cotinine
Saliva
Waxes
Mastication
Nicotine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Schneider, N. G., Jacob, P., Nilsson, F., Leischow, S., Benowitz, N. L., & Olmstead, R. E. (1997). Saliva cotinine levels as a function of collection method. Addiction, 92(3), 347-351. https://doi.org/10.1111/j.1360-0443.1997.tb03204.x

Saliva cotinine levels as a function of collection method. / Schneider, Nina G.; Jacob, Peyton; Nilsson, Fredrik; Leischow, Scott; Benowitz, Neal L.; Olmstead, Richard E.

In: Addiction, Vol. 92, No. 3, 11.04.1997, p. 347-351.

Research output: Contribution to journalArticle

Schneider, NG, Jacob, P, Nilsson, F, Leischow, S, Benowitz, NL & Olmstead, RE 1997, 'Saliva cotinine levels as a function of collection method', Addiction, vol. 92, no. 3, pp. 347-351. https://doi.org/10.1111/j.1360-0443.1997.tb03204.x
Schneider NG, Jacob P, Nilsson F, Leischow S, Benowitz NL, Olmstead RE. Saliva cotinine levels as a function of collection method. Addiction. 1997 Apr 11;92(3):347-351. https://doi.org/10.1111/j.1360-0443.1997.tb03204.x
Schneider, Nina G. ; Jacob, Peyton ; Nilsson, Fredrik ; Leischow, Scott ; Benowitz, Neal L. ; Olmstead, Richard E. / Saliva cotinine levels as a function of collection method. In: Addiction. 1997 ; Vol. 92, No. 3. pp. 347-351.
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