Risky decision-making in older adults without cognitive deficits: An fMRI study of VMPFC using the Iowa Gambling Task

Corianne Reddy, Christine Vidal, Xiangrui Li, Hanna Damasio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Some older adults without neurological disease exhibit impaired decision-making in risky, nontransparent situations, like the Iowa Gambling Task (IGT). The prefrontal cortices are particularly vulnerable to age-related decline, and numerous studies implicate the ventromedial prefrontal cortex (VMPFC) in successful IGT performance. However, the relationship between IGT performance and VMPFC function in older adults has not yet been tested by fMRI. In the present study, older adults with seemingly no cognitive impairments performed the IGT and a non-gambling control task during fMRI. Group analyses indicate that in these older adults, regardless of IGT performance level, a right VMPFC subregion is activated during the IGT, while successful IGT performance is correlated with left VMPFC activation, suggesting that bilateral VMPFC during risky, nontransparent situations may contribute to successful decision-making in older adults. Individual subject analyses reveal substantial variation regarding the extent and location of VMPFC activation during the IGT, a finding not captured in the group analysis: There is no correlation between IGT performance and extent of activation in the right VMPFC, although there is such a correlation between left VMPFC activation and IGT performance.

Original languageEnglish (US)
Pages (from-to)178-190
Number of pages13
JournalSocial Neuroscience
Volume7
Issue number2
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

gambling
Gambling
Prefrontal Cortex
Decision Making
deficit
Magnetic Resonance Imaging
decision making
Task Performance and Analysis
activation
performance
Group

Keywords

  • Aging
  • Decision-making
  • fMRI
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Development
  • Social Psychology

Cite this

Risky decision-making in older adults without cognitive deficits : An fMRI study of VMPFC using the Iowa Gambling Task. / Reddy, Corianne; Vidal, Christine; Li, Xiangrui; Damasio, Hanna.

In: Social Neuroscience, Vol. 7, No. 2, 03.2012, p. 178-190.

Research output: Contribution to journalArticle

@article{3150e9a88bbd4ea6a0a488978bf55690,
title = "Risky decision-making in older adults without cognitive deficits: An fMRI study of VMPFC using the Iowa Gambling Task",
abstract = "Some older adults without neurological disease exhibit impaired decision-making in risky, nontransparent situations, like the Iowa Gambling Task (IGT). The prefrontal cortices are particularly vulnerable to age-related decline, and numerous studies implicate the ventromedial prefrontal cortex (VMPFC) in successful IGT performance. However, the relationship between IGT performance and VMPFC function in older adults has not yet been tested by fMRI. In the present study, older adults with seemingly no cognitive impairments performed the IGT and a non-gambling control task during fMRI. Group analyses indicate that in these older adults, regardless of IGT performance level, a right VMPFC subregion is activated during the IGT, while successful IGT performance is correlated with left VMPFC activation, suggesting that bilateral VMPFC during risky, nontransparent situations may contribute to successful decision-making in older adults. Individual subject analyses reveal substantial variation regarding the extent and location of VMPFC activation during the IGT, a finding not captured in the group analysis: There is no correlation between IGT performance and extent of activation in the right VMPFC, although there is such a correlation between left VMPFC activation and IGT performance.",
keywords = "Aging, Decision-making, fMRI, Ventromedial prefrontal cortex",
author = "Corianne Reddy and Christine Vidal and Xiangrui Li and Hanna Damasio",
year = "2012",
month = "3",
doi = "10.1080/17470919.2011.588340",
language = "English (US)",
volume = "7",
pages = "178--190",
journal = "Social Neuroscience",
issn = "1747-0919",
publisher = "Psychology Press Ltd",
number = "2",

}

TY - JOUR

T1 - Risky decision-making in older adults without cognitive deficits

T2 - An fMRI study of VMPFC using the Iowa Gambling Task

AU - Reddy, Corianne

AU - Vidal, Christine

AU - Li, Xiangrui

AU - Damasio, Hanna

PY - 2012/3

Y1 - 2012/3

N2 - Some older adults without neurological disease exhibit impaired decision-making in risky, nontransparent situations, like the Iowa Gambling Task (IGT). The prefrontal cortices are particularly vulnerable to age-related decline, and numerous studies implicate the ventromedial prefrontal cortex (VMPFC) in successful IGT performance. However, the relationship between IGT performance and VMPFC function in older adults has not yet been tested by fMRI. In the present study, older adults with seemingly no cognitive impairments performed the IGT and a non-gambling control task during fMRI. Group analyses indicate that in these older adults, regardless of IGT performance level, a right VMPFC subregion is activated during the IGT, while successful IGT performance is correlated with left VMPFC activation, suggesting that bilateral VMPFC during risky, nontransparent situations may contribute to successful decision-making in older adults. Individual subject analyses reveal substantial variation regarding the extent and location of VMPFC activation during the IGT, a finding not captured in the group analysis: There is no correlation between IGT performance and extent of activation in the right VMPFC, although there is such a correlation between left VMPFC activation and IGT performance.

AB - Some older adults without neurological disease exhibit impaired decision-making in risky, nontransparent situations, like the Iowa Gambling Task (IGT). The prefrontal cortices are particularly vulnerable to age-related decline, and numerous studies implicate the ventromedial prefrontal cortex (VMPFC) in successful IGT performance. However, the relationship between IGT performance and VMPFC function in older adults has not yet been tested by fMRI. In the present study, older adults with seemingly no cognitive impairments performed the IGT and a non-gambling control task during fMRI. Group analyses indicate that in these older adults, regardless of IGT performance level, a right VMPFC subregion is activated during the IGT, while successful IGT performance is correlated with left VMPFC activation, suggesting that bilateral VMPFC during risky, nontransparent situations may contribute to successful decision-making in older adults. Individual subject analyses reveal substantial variation regarding the extent and location of VMPFC activation during the IGT, a finding not captured in the group analysis: There is no correlation between IGT performance and extent of activation in the right VMPFC, although there is such a correlation between left VMPFC activation and IGT performance.

KW - Aging

KW - Decision-making

KW - fMRI

KW - Ventromedial prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=84858791430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858791430&partnerID=8YFLogxK

U2 - 10.1080/17470919.2011.588340

DO - 10.1080/17470919.2011.588340

M3 - Article

C2 - 21864197

AN - SCOPUS:84858791430

VL - 7

SP - 178

EP - 190

JO - Social Neuroscience

JF - Social Neuroscience

SN - 1747-0919

IS - 2

ER -