Resibufogenin corrects hypertension in a rat model of human preeclampsia

Hop Vu; Monica Ianosi-Irimie; Svitlana Danchuk; Edd Rabon; Toshihiko Nogawa; Yoshiaki Kamano; George Pettit; Thomas Wiese; Jules B. Puschett

doi:10.1177/153537020623100212

Resibufogenin corrects hypertension in a rat model of human preeclampsia

Hop Vu, Monica Ianosi-Irimie, Svitlana Danchuk, Edd Rabon, Toshihiko Nogawa, Yoshiaki Kamano, George Pettit, Thomas Wiese, Jules B. Puschett

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32 Scopus citations

Abstract

The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	Experimental Biology and Medicine
Volume	231
Issue number	2
DOIs	https://doi.org/10.1177/153537020623100212
State	Published - Feb 2006

Keywords

Hypertension
Preeclampsia
Pregnancy
Volume-expansion

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1177/153537020623100212

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abstract = "The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.",

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AU - Vu, Hop

AU - Ianosi-Irimie, Monica

AU - Danchuk, Svitlana

AU - Rabon, Edd

AU - Nogawa, Toshihiko

AU - Kamano, Yoshiaki

AU - Pettit, George

AU - Wiese, Thomas

AU - Puschett, Jules B.

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AB - The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.

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KW - Pregnancy

KW - Volume-expansion

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Resibufogenin corrects hypertension in a rat model of human preeclampsia

Abstract

Keywords

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