Resibufogenin corrects hypertension in a rat model of human preeclampsia

Hop Vu, Monica Ianosi-Irimie, Svitlana Danchuk, Edd Rabon, Toshihiko Nogawa, Yoshiaki Kamano, George Pettit, Thomas Wiese, Jules B. Puschett

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalExperimental Biology and Medicine
Volume231
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Hypertension
  • Preeclampsia
  • Pregnancy
  • Volume-expansion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Vu, H., Ianosi-Irimie, M., Danchuk, S., Rabon, E., Nogawa, T., Kamano, Y., Pettit, G., Wiese, T., & Puschett, J. B. (2006). Resibufogenin corrects hypertension in a rat model of human preeclampsia. Experimental Biology and Medicine, 231(2), 215-220. https://doi.org/10.1177/153537020623100212