Repertoire development and the control of cytotoxic/effector function in human δ T cells

C. David Pauza, Elizabeth M. Urban, Andrei I. Chapoval

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the αβ TCR generally express CD4 or CD8 lineagemarkers andmostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate γδ TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens.We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on γδ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells. A unique mechanism for MHC-independent repertoire selection is linked to the control of effector function that is vital to the role for γδ T cells in tumor surveillance. Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy.

Original languageEnglish (US)
Article number732893
JournalClinical and Developmental Immunology
Volume2010
DOIs
StatePublished - May 24 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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