Relation of epidermal growth factor receptor and estrogen receptor- independent pS2 protein to the malignant transformation of mucinous cystic neoplasms of the pancreas

R. E. Kirby, K. B. Lewandrowski, J. F. Southern, Carolyn Compton, A. L. Warshaw

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Abstract

Objective: To evaluate the role of epidermal growth factor receptor (EGF- R) and pS2 protein in the evolution of malignancy in mucinous cystic tumors of the pancreas. Background: Mucinous cystic tumors of the pancreas include histologically benign but premalignant mucinous cystic neoplasms and mutinous cystadenocarcinoma. The molecular events leading to transformation from a benign to a malignant mucinous tumor are not known. Overexpression of EGF-R and detection of an estrogen-induced protein (pS2) has been demonstrated in ductal adenocarcinomas of the pancreas, but these factors have not been evaluated in mucinous cystic tumors. Design: Twenty-six mucinous tumors were examined for EGF-R, pS2 protein, and estrogen and progesterone receptors. Results: Eight (61.2%) of 13 malignant tumors exhibited increased expression of EGF-R, whereas EGF-R was not detected in any of the 13 benign tumors (P=.002). The pS2 protein was detected in nine of 11 malignant and 11 of 11 benign tumors (P=.480). Estrogen and progesterone receptors were not detected in the epithelium of either tumor type. The median survival time of the patients with EGF-R-negative tumors was 29.0 months compared with 14.5 months for those with EGF-R-positive tumors, but this difference did not reach significance owing to the small population size. Conclusions: Overexpression of EGF-R in mucinous cystic tumors, as in ductal adenocarcinomas, may be an important feature associated with malignancy and may have prognostic significance. Failure to detect EGF-R in histologically benign epithelium suggests that the upregulation of EGF-R may be important in the evolution of aggressive behavior. The expression of pS2 protein appears to be independent of estrogen and may play a role in the proliferative activity of mucinous tumors. However, pS2 expression is not a feature associated exclusively with malignancy.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalArchives of Surgery
Volume130
Issue number1
StatePublished - 1995
Externally publishedYes

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Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Estrogen Receptors
Epidermal Growth Factor
Neoplasms
Pancreas
Trefoil Factor-1
Progesterone Receptors
Estrogens
Adenocarcinoma
Epithelium
Cystadenocarcinoma
Population Density

ASJC Scopus subject areas

  • Surgery

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Relation of epidermal growth factor receptor and estrogen receptor- independent pS2 protein to the malignant transformation of mucinous cystic neoplasms of the pancreas. / Kirby, R. E.; Lewandrowski, K. B.; Southern, J. F.; Compton, Carolyn; Warshaw, A. L.

In: Archives of Surgery, Vol. 130, No. 1, 1995, p. 69-72.

Research output: Contribution to journalArticle

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abstract = "Objective: To evaluate the role of epidermal growth factor receptor (EGF- R) and pS2 protein in the evolution of malignancy in mucinous cystic tumors of the pancreas. Background: Mucinous cystic tumors of the pancreas include histologically benign but premalignant mucinous cystic neoplasms and mutinous cystadenocarcinoma. The molecular events leading to transformation from a benign to a malignant mucinous tumor are not known. Overexpression of EGF-R and detection of an estrogen-induced protein (pS2) has been demonstrated in ductal adenocarcinomas of the pancreas, but these factors have not been evaluated in mucinous cystic tumors. Design: Twenty-six mucinous tumors were examined for EGF-R, pS2 protein, and estrogen and progesterone receptors. Results: Eight (61.2{\%}) of 13 malignant tumors exhibited increased expression of EGF-R, whereas EGF-R was not detected in any of the 13 benign tumors (P=.002). The pS2 protein was detected in nine of 11 malignant and 11 of 11 benign tumors (P=.480). Estrogen and progesterone receptors were not detected in the epithelium of either tumor type. The median survival time of the patients with EGF-R-negative tumors was 29.0 months compared with 14.5 months for those with EGF-R-positive tumors, but this difference did not reach significance owing to the small population size. Conclusions: Overexpression of EGF-R in mucinous cystic tumors, as in ductal adenocarcinomas, may be an important feature associated with malignancy and may have prognostic significance. Failure to detect EGF-R in histologically benign epithelium suggests that the upregulation of EGF-R may be important in the evolution of aggressive behavior. The expression of pS2 protein appears to be independent of estrogen and may play a role in the proliferative activity of mucinous tumors. However, pS2 expression is not a feature associated exclusively with malignancy.",
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T1 - Relation of epidermal growth factor receptor and estrogen receptor- independent pS2 protein to the malignant transformation of mucinous cystic neoplasms of the pancreas

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AU - Compton, Carolyn

AU - Warshaw, A. L.

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N2 - Objective: To evaluate the role of epidermal growth factor receptor (EGF- R) and pS2 protein in the evolution of malignancy in mucinous cystic tumors of the pancreas. Background: Mucinous cystic tumors of the pancreas include histologically benign but premalignant mucinous cystic neoplasms and mutinous cystadenocarcinoma. The molecular events leading to transformation from a benign to a malignant mucinous tumor are not known. Overexpression of EGF-R and detection of an estrogen-induced protein (pS2) has been demonstrated in ductal adenocarcinomas of the pancreas, but these factors have not been evaluated in mucinous cystic tumors. Design: Twenty-six mucinous tumors were examined for EGF-R, pS2 protein, and estrogen and progesterone receptors. Results: Eight (61.2%) of 13 malignant tumors exhibited increased expression of EGF-R, whereas EGF-R was not detected in any of the 13 benign tumors (P=.002). The pS2 protein was detected in nine of 11 malignant and 11 of 11 benign tumors (P=.480). Estrogen and progesterone receptors were not detected in the epithelium of either tumor type. The median survival time of the patients with EGF-R-negative tumors was 29.0 months compared with 14.5 months for those with EGF-R-positive tumors, but this difference did not reach significance owing to the small population size. Conclusions: Overexpression of EGF-R in mucinous cystic tumors, as in ductal adenocarcinomas, may be an important feature associated with malignancy and may have prognostic significance. Failure to detect EGF-R in histologically benign epithelium suggests that the upregulation of EGF-R may be important in the evolution of aggressive behavior. The expression of pS2 protein appears to be independent of estrogen and may play a role in the proliferative activity of mucinous tumors. However, pS2 expression is not a feature associated exclusively with malignancy.

AB - Objective: To evaluate the role of epidermal growth factor receptor (EGF- R) and pS2 protein in the evolution of malignancy in mucinous cystic tumors of the pancreas. Background: Mucinous cystic tumors of the pancreas include histologically benign but premalignant mucinous cystic neoplasms and mutinous cystadenocarcinoma. The molecular events leading to transformation from a benign to a malignant mucinous tumor are not known. Overexpression of EGF-R and detection of an estrogen-induced protein (pS2) has been demonstrated in ductal adenocarcinomas of the pancreas, but these factors have not been evaluated in mucinous cystic tumors. Design: Twenty-six mucinous tumors were examined for EGF-R, pS2 protein, and estrogen and progesterone receptors. Results: Eight (61.2%) of 13 malignant tumors exhibited increased expression of EGF-R, whereas EGF-R was not detected in any of the 13 benign tumors (P=.002). The pS2 protein was detected in nine of 11 malignant and 11 of 11 benign tumors (P=.480). Estrogen and progesterone receptors were not detected in the epithelium of either tumor type. The median survival time of the patients with EGF-R-negative tumors was 29.0 months compared with 14.5 months for those with EGF-R-positive tumors, but this difference did not reach significance owing to the small population size. Conclusions: Overexpression of EGF-R in mucinous cystic tumors, as in ductal adenocarcinomas, may be an important feature associated with malignancy and may have prognostic significance. Failure to detect EGF-R in histologically benign epithelium suggests that the upregulation of EGF-R may be important in the evolution of aggressive behavior. The expression of pS2 protein appears to be independent of estrogen and may play a role in the proliferative activity of mucinous tumors. However, pS2 expression is not a feature associated exclusively with malignancy.

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