TY - JOUR
T1 - Purging inbreeding depression and the probability of extinction
T2 - Full-sib mating
AU - Hedrick, P. W.
N1 - Funding Information:
Phil Miller and several anonymous reviewers on an earlier draft of the manuscript. This research was supported by NSF BRF-8923007.
PY - 1994/10
Y1 - 1994/10
N2 - Inbreeding depression has been a topic of interest in recent years from a number of perspectives, particularly in the captive breeding of endangered species. Generally, the goal of captive breeding is to avoid the detrimental effects of inbreeding depression and to retain genetic variation for future adaptation. However, an important component of another suggested approach to captive breeding is to purge rapidly the population of its genetic load so that its long-term fitness is not compromised. I have examined the effectiveness of purging the genetic load by documenting both the reduction in inbreeding depression and the increase of the probability of extinction when there is continous full- sib mating. When the genetic load is the result of lethals, the inbreeding depression is quickly purged without a high probability of extinction, except when the total genetic load is high. On the other hand, if the load is due to detrimentals of relatively small effect, the genetic load becomes fixed, the mean fitness is reduced, and the probability of extinction may be greatly increased. In other words, the success of such a programme to purge genetic load without an increase in the probability of extinction is highly dependent, upon the genetic basis of inbreeding depression, information that is not readily available for most species.
AB - Inbreeding depression has been a topic of interest in recent years from a number of perspectives, particularly in the captive breeding of endangered species. Generally, the goal of captive breeding is to avoid the detrimental effects of inbreeding depression and to retain genetic variation for future adaptation. However, an important component of another suggested approach to captive breeding is to purge rapidly the population of its genetic load so that its long-term fitness is not compromised. I have examined the effectiveness of purging the genetic load by documenting both the reduction in inbreeding depression and the increase of the probability of extinction when there is continous full- sib mating. When the genetic load is the result of lethals, the inbreeding depression is quickly purged without a high probability of extinction, except when the total genetic load is high. On the other hand, if the load is due to detrimentals of relatively small effect, the genetic load becomes fixed, the mean fitness is reduced, and the probability of extinction may be greatly increased. In other words, the success of such a programme to purge genetic load without an increase in the probability of extinction is highly dependent, upon the genetic basis of inbreeding depression, information that is not readily available for most species.
KW - Captive breeding
KW - Full-sib mating
KW - Genetic load
KW - Inbreeding depression
KW - Lethals
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U2 - 10.1038/hdy.1994.183
DO - 10.1038/hdy.1994.183
M3 - Article
C2 - 7989216
AN - SCOPUS:0028519058
SN - 0018-067X
VL - 73
SP - 363
EP - 372
JO - Heredity
JF - Heredity
IS - 4
ER -