Public vaccination policy using an age-structured model of pneumococcal infection dynamics

Karyn L. Sutton, H. T. Banks, Carlos Castillo-Chavez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Public health professionals are charged with the task of designing prevention programs for the effective control of biologically intricate infectious diseases at a population level. The effective vaccination of a population for pneumococcal diseases (infections caused by Streptococcus pneumoniae) remains a relevant question in the scientific community. It is complicated by heterogeneity in individuals' responses to exposure to the bacterium and their responses to vaccination. Due to these complexities, most modelling efforts in this area have been on the cellular/bacteria level. Here, we introduce an age-structured SEIS-type model of pneumococcal diseases and their vaccination. We discuss the use of this framework in predicting the impact of vaccine strategies, with pneumococcal diseases as an example. Using parameter values reasonable for a developed country, we discuss the effects of targeting the colonization and/or infection stages on the age profiles of morbidity in a population.

Original languageEnglish (US)
Pages (from-to)176-195
Number of pages20
JournalJournal of biological dynamics
Volume4
Issue number2
DOIs
StatePublished - Mar 2010

Keywords

  • Mathematical model
  • Pneumococcal infections
  • Vaccine strategies

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

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