Public health implications of Marek's disease virus and herpesvirus of turkeys. Studies on human and subhuman primates

J. M. Sharma, R. L. Witter, B. R. Burmester, J. C. Landon

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Abstract

Cynomolgus, rhesus, and bonnet monkeys inoculated with high doses of herpesvirus of turkeys (HVT) or pathogenic Marek's disease virus (MDV) were observed for 11-31 months. None developed detectable viremia, hematologic abnormalities, or clinical disease. Sera from 3 of 12 monkeys inoculated with HVT reacted against HVT antigen in an immunofluorescence (IF) test, whereas all 8 MDV inoculated monkeys remained negative. Approximately 15 months after initial inoculation, 1 reactor and 1 nonreactor monkey from the HVT inoculated group were given a second injection of cell associated HVT propagated in duck embryo fibroblast (DEF) cells. One reactor and 1 nonreactor from the same group received normal DEF cells. Virus inoculated animals developed IF reactions against HVT, but the 2 animals inoculated with normal DEF cells remained negative. Sera from people in 7 different categories, including those with prolonged contact with HVT and MDV, were tested by IF test for HVT and MDV antibody. Of approximately 200 sera, 8% had IF reactions. There was no apparent correlation between the extent of the 2 viruses and the incidence of IF reaction. Of 25 sera from Burkitt's lymphoma patients, 1 serum had a weak (1:5) reaction against MDV antigen. Human and monkey sera positive by the IF test lacked specific virus neutralizing activity. The significance of IF reaction, therefore, remained unclear. These data supported earlier findings and provided additional circumstantial evidence that MDV and HVT do not constitute a public health hazard.

Original languageEnglish (US)
Pages (from-to)1123-1128
Number of pages6
JournalJournal of the National Cancer Institute
Volume51
Issue number4
StatePublished - 1973
Externally publishedYes

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Meleagrid Herpesvirus 1
Marek Disease
Primates
Public Health
Fluorescent Antibody Technique
Viruses
Haplorhini
Ducks
Serum
Embryonic Structures
Fibroblasts
Macaca radiata
Antigens
Macaca fascicularis
Burkitt Lymphoma
Viremia
Macaca mulatta

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Public health implications of Marek's disease virus and herpesvirus of turkeys. Studies on human and subhuman primates. / Sharma, J. M.; Witter, R. L.; Burmester, B. R.; Landon, J. C.

In: Journal of the National Cancer Institute, Vol. 51, No. 4, 1973, p. 1123-1128.

Research output: Contribution to journalArticle

Sharma, J. M. ; Witter, R. L. ; Burmester, B. R. ; Landon, J. C. / Public health implications of Marek's disease virus and herpesvirus of turkeys. Studies on human and subhuman primates. In: Journal of the National Cancer Institute. 1973 ; Vol. 51, No. 4. pp. 1123-1128.
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