Promotion of accelerated healing in a mouse wound model with a viral immunomodulator serp-1/chitosan gel

Liqiang Zhang, Jordan R. Yaron, Sarah Wallace, Michelle Burgin, Amanda Tafoya, Alexandra R. Lucas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Skin wounds are now considered as one of the major threats to public health and the economy. Based on understanding of the mechanisms of wound healing, numerous therapeutic methods have been developed to promote accelerated wound healing, including slow-release hydrogels for small molecules or growth factors delivery. In this study, we applied the viral immunomodulatory protein Serp-1, a serine proteinase inhibitor (serpin), to promote accelerated wound healing. Serp-1 is a purified, secreted 55kDa glycoprotein derived from Myxomavirus that interferes with the inflammation processes of its host, the European rabbit (Oryctolagus cuniculus) [1]. Our systematic studies on Serp-1 protein demonstrate highly potent anti-inflammatory functions in a wide range of animal models of vascular disease and transplant. Serp-1 also significantly reduced markers of heart damage in a small Phase 2 clinical trial. Serp-1 proved safe in animal models and in Phase I and Phase 2a clinical trials in humans [2]. We examined local delivery of Serp-1 in a hydrogel and assessed wound healing with topical Serp-1 treatment. Topical delivery methods for Serp-1 wound treatments were compared to determine the optimal application approach.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages508
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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