TY - JOUR
T1 - Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering
AU - Gangrade, Ankit
AU - Stephanopoulos, Nicholas
AU - Bhatia, Dhiraj
N1 - Funding Information:
We sincerely thank all the members of DB group for critically reading the manuscript and their valuable feedback. AG thanks IITGN-MHRD, GoI for postdoctoral fellowship. DB thanks SERB, GoI for Ramanujan Fellowship, DBT-GoI, BRNS-BARC, GSBTM and Gujcost for research funding.
Publisher Copyright:
© 2021 The Royal Society of Chemistry.
PY - 2021/10/28
Y1 - 2021/10/28
N2 - DNA-based nanotechnology has evolved into an autonomous, highly innovative, and dynamic field of research at the nexus of supramolecular chemistry, nanotechnology, materials science, and biotechnology. DNA-based materials, including origami nanodevices, have started to emerge as an ideal scaffold for use in cellular programming, tissue engineering, and drug delivery applications. We cover herein the applications for DNA as a scaffold for interfacing with, and guiding, the activity of biological systems like cells and tissues. Although DNA is a highly programmable molecular building block, it suffers from a lack of functional capacity for guiding and modulating cells. Coupling DNA to biologically active molecules can bestow bioactivity to these nanodevices. The main goal of such nanodevices is to synthesize systems that can bind to cells and mimic the extracellular environment, and serve as a highly promising toolbox for multiple applications in cellular programming and tissue engineering. DNA-based programmable devices offer a highly promising approach for programming collections of cells, tissue engineering, and regenerative medicine applications.
AB - DNA-based nanotechnology has evolved into an autonomous, highly innovative, and dynamic field of research at the nexus of supramolecular chemistry, nanotechnology, materials science, and biotechnology. DNA-based materials, including origami nanodevices, have started to emerge as an ideal scaffold for use in cellular programming, tissue engineering, and drug delivery applications. We cover herein the applications for DNA as a scaffold for interfacing with, and guiding, the activity of biological systems like cells and tissues. Although DNA is a highly programmable molecular building block, it suffers from a lack of functional capacity for guiding and modulating cells. Coupling DNA to biologically active molecules can bestow bioactivity to these nanodevices. The main goal of such nanodevices is to synthesize systems that can bind to cells and mimic the extracellular environment, and serve as a highly promising toolbox for multiple applications in cellular programming and tissue engineering. DNA-based programmable devices offer a highly promising approach for programming collections of cells, tissue engineering, and regenerative medicine applications.
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U2 - 10.1039/d1nr04475c
DO - 10.1039/d1nr04475c
M3 - Review article
C2 - 34622910
AN - SCOPUS:85118173681
SN - 2040-3364
VL - 13
SP - 16834
EP - 16846
JO - Nanoscale
JF - Nanoscale
IS - 40
ER -