Production of tumor necrosis factor alpha, interleukin-1α, and interleukin-6 during murine coccidioidomycosis

R. A. Cox, D. M. Magee

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1α (IL-1α), and interleukin-6 (IL-6) were induced in mice infected with Coccidioides immitis. Analyses of the cytokine profiles of two inbred mouse strains which differ in their susceptibility to pulmonary challenge with C. immitis revealed higher levels of IL-6 in lungs from DBA/2 mice (resistant strain) than in those from BALB/c mice (susceptible strain) beginning at day 6 and continuing through day 15 postinfection. Spleen cells from both mouse strains secreted TNF-α, IL-1α, and IL-6 in vitro in response to stimulation with killed spherules but differed in that spleen cells from the resistant strain produced increased levels of these cytokines earlier after pulmonary challenge and at increased levels throughout the course of the disease.

Original languageEnglish (US)
Pages (from-to)4178-4180
Number of pages3
JournalInfection and immunity
Volume63
Issue number10
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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