Production of tumor necrosis factor alpha, interleukin-1α, and interleukin-6 during murine coccidioidomycosis

R. A. Cox, Dewey Magee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1α (IL-1α), and interleukin-6 (IL-6) were induced in mice infected with Coccidioides immitis. Analyses of the cytokine profiles of two inbred mouse strains which differ in their susceptibility to pulmonary challenge with C. immitis revealed higher levels of IL-6 in lungs from DBA/2 mice (resistant strain) than in those from BALB/c mice (susceptible strain) beginning at day 6 and continuing through day 15 postinfection. Spleen cells from both mouse strains secreted TNF-α, IL-1α, and IL-6 in vitro in response to stimulation with killed spherules but differed in that spleen cells from the resistant strain produced increased levels of these cytokines earlier after pulmonary challenge and at increased levels throughout the course of the disease.

Original languageEnglish (US)
Pages (from-to)4178-4180
Number of pages3
JournalInfection and Immunity
Volume63
Issue number10
StatePublished - 1995
Externally publishedYes

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Coccidioidomycosis
Interleukin-1
Coccidioides
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Lung
Spleen
Inbred DBA Mouse
Inbred Strains Mice

ASJC Scopus subject areas

  • Immunology

Cite this

Production of tumor necrosis factor alpha, interleukin-1α, and interleukin-6 during murine coccidioidomycosis. / Cox, R. A.; Magee, Dewey.

In: Infection and Immunity, Vol. 63, No. 10, 1995, p. 4178-4180.

Research output: Contribution to journalArticle

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