Probing changes in neural interaction during adaptation

Liqiang Zhu, Ying-Cheng Lai, Frank C. Hoppensteadt, Jiping He

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A procedure is developed to probe the changes in the functional interactions among neurons in primary motor cortex of the monkey brain during adaptation. A monkey is trained to learn a new skill, moving its arm to reach a target under the influence of external perturbations. The spike trains of multiple neurons in the primary motor cortex are recorded simultaneously. We utilize the methodology of directed transfer function, derived from a class of linear stochastic models, to quantify the causal interactions between the neurons. We find that the coupling between the motor neurons tends to increase during the adaptation but return to the original level after the adaptation. Furthermore, there is evidence that adaptation tends to affect the topology of the neural network, despite the approximate conservation of the average coupling strength in the network before and after the adaptation.

Original languageEnglish (US)
Pages (from-to)2359-2377
Number of pages19
JournalNeural Computation
Volume15
Issue number10
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Probing changes in neural interaction during adaptation'. Together they form a unique fingerprint.

Cite this