Preventing mental retardation associated with gross obesity in the Prader-Willi syndrome

K. A. Crnic; S. Sulzbacher; V. A. Holm; J. Snow

Preventing mental retardation associated with gross obesity in the Prader-Willi syndrome

K. A. Crnic, S. Sulzbacher, V. A. Holm, J. Snow

Arizona State University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

27 patients with Prader-Willi syndrome have been described, ten of whom did not receive comprehensive management, nine who were diagnosed and treated after becoming obese, and eight who were diagnosed in infancy and responded to early preventative treatment. Intelligence scores declined in the first two groups, but the group receiving early treatment maintained a mean IQ score 20 points higher than the other two. Even though the underlying mechanism of this disorder remains undefined, a comprehensive early intervention program appears to improve prognosis.

Original language	English (US)
Pages (from-to)	787-789
Number of pages	3
Journal	Pediatrics
Volume	66
Issue number	5
State	Published - Dec 1 1980

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

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N2 - 27 patients with Prader-Willi syndrome have been described, ten of whom did not receive comprehensive management, nine who were diagnosed and treated after becoming obese, and eight who were diagnosed in infancy and responded to early preventative treatment. Intelligence scores declined in the first two groups, but the group receiving early treatment maintained a mean IQ score 20 points higher than the other two. Even though the underlying mechanism of this disorder remains undefined, a comprehensive early intervention program appears to improve prognosis.

AB - 27 patients with Prader-Willi syndrome have been described, ten of whom did not receive comprehensive management, nine who were diagnosed and treated after becoming obese, and eight who were diagnosed in infancy and responded to early preventative treatment. Intelligence scores declined in the first two groups, but the group receiving early treatment maintained a mean IQ score 20 points higher than the other two. Even though the underlying mechanism of this disorder remains undefined, a comprehensive early intervention program appears to improve prognosis.

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Preventing mental retardation associated with gross obesity in the Prader-Willi syndrome

Abstract

ASJC Scopus subject areas

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