TY - JOUR
T1 - Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists
AU - Gatz, Margaret
AU - Mack, Wendy J.
AU - Chui, Helena C.
AU - Law, E. Meng
AU - Barisano, Giuseppe
AU - Sutherland, M. Linda
AU - Sutherland, James D.
AU - Eid Rodriguez, Daniel
AU - Quispe Gutierrez, Raul
AU - Copajira Adrian, Juan
AU - Bani Cuata, Jesus
AU - Borenstein, Amy R.
AU - Walters, Ellen E.
AU - Irimia, Andrei
AU - Rowan, Christopher J.
AU - Wann, L. Samuel
AU - Allam, Adel H.
AU - Thompson, Randall C.
AU - Miyamoto, Michael I.
AU - Michalik, David E.
AU - Cummings, Daniel K.
AU - Seabright, Edmond
AU - Garcia, Angela R.
AU - Hooper, Paul L.
AU - Kraft, Thomas S.
AU - Finch, Caleb E.
AU - Thomas, Gregory S.
AU - Stieglitz, Jonathan
AU - Trumble, Benjamin C.
AU - Gurven, Michael D.
AU - Kaplan, Hillard
N1 - Funding Information:
This work was financially supported by the National Institutes of Health Grant No. RF1 AG054442. Jonathan Stieglitz acknowledges the Institute for Advanced Study in Toulouse (IAST) funding from the French National Research Agency (ANR) under grant ANR‐17‐EURE‐0010 (Investissements d'Avenir program). The authors thank the Tsimane and Moseten participants, the Gran Consejo Tsimane (GCT), the Consejo Regional Tsimane Moseten (CRTM) and the Organización del Pueblo Indígena Mosetén (OPIM), the Tsimane Health and Life History Project staff in San Borja, Bolivia, and the Hospital Presidente German Busch of Trinidad, Bolivia.
Funding Information:
This work was financially supported by the National Institutes of Health Grant No. RF1 AG054442. Jonathan Stieglitz acknowledges the Institute for Advanced Study in Toulouse (IAST) funding from the French National Research Agency (ANR) under grant ANR-17-EURE-0010 (Investissements d'Avenir program). The authors thank the Tsimane and Moseten participants, the Gran Consejo Tsimane (GCT), the Consejo Regional Tsimane Moseten (CRTM) and the Organización del Pueblo Indígena Mosetén (OPIM), the Tsimane Health and Life History Project staff in San Borja, Bolivia, and the Hospital Presidente German Busch of Trinidad, Bolivia.
Funding Information:
Margaret Gatz, Wendy J. Mack, Helena C. Chui, E. Meng Law, Giuseppe Barisano, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Amy R. Borenstein, Ellen E. Walters, Andrei Irimia, Christopher J. Rowan, Edmond Seabright, Angela R. Garcia, Paul L. Hooper, Thomas S. Kraft, Caleb E. Finch, Gregory S. Thomas, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, and Hillard Kaplan received support from the National Institutes of Health (NIH) Grant No. RF1 AG054442, through the main grant (to Chapman University), a subcontract from the main grant to their institution, or a contract to them personally from one of the participating institutions. Outside of the submitted work, E. Meng Law, M. Linda Sutherland, James D. Sutherland, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, L. Samuel Wann, Adel H. Allam, David E. Michalik, Daniel K. Cummings, Edmond Seabright, Paul L. Hooper, Thomas S. Kraft, Benjamin C. Trumble, Michael D. Gurven, and Hillard Kaplan report no disclosures. Margaret Gatz receives research grant support from NIH. Wendy J. Mack receives research grant support from NIH and payments from four Data Safety and Monitoring Boards for clinical trials. Helena C. Chui receives research grant support from the NIH and consulting fees as an external advisory committee member for Oregon Health Sciences University, and is a Board Member of Alzheimer Los Angeles (no payment). Giuseppe Barisano receives research grant support from the NIH and received a royalty from Elsevier. Daniel Eid Rodriguez received funding from Swedish International Development Cooperation Agency for travel related to research training. Amy R. Borenstein received royalties from Academic Press. Ellen E. Walters is an independent contractor on NIH research grants. Andrei Irimia receives research grant support from the NIH. Christopher J. Rowan has a relationship with Zoll for LifeVest and a patent for software for flying. Randall C. Thompson is President: American Society of Nuclear Cardiology (payment to institution) and Chair: Coding Task Force; American College of Cardiology (no payment). Michael I. Miyamoto has a relationship with Hegeler and Anderson, LLP, and is a board member of Vallum Corp (no payment). Angela R. Garcia received an NIH Butler‐Williams Scholarship (no payment). Caleb E. Finch receives research grant support from the NIH and US DoD; consults for Cure Alz Fund; holds stock in Acumen Pharmaceuticals; and receives royalties from Elsevier and University of Chicago Press. Gregory S. Thomas received Astellas Pharma speaker's bureau fees and royalties from Oxford University Press. Jonathan Stieglitz holds a research grant from the National Science Foundation (NSF) (no payment); receives consulting fees as a member of an advisory board for a project funded by Templeton; and is a board member for One Pencil Project (no payment).
Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/1
Y1 - 2023/1
N2 - Introduction: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods: Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
AB - Introduction: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods: Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
KW - Moseten
KW - Tsimane
KW - cognitive dysfunction
KW - dementia
KW - mental status and dementia tests
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U2 - 10.1002/alz.12626
DO - 10.1002/alz.12626
M3 - Article
C2 - 35262289
AN - SCOPUS:85126000223
SN - 1552-5260
VL - 19
SP - 44
EP - 55
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 1
ER -