Abstract

The hemofiltration/molecular separation (HFMS) artificial kidney concept, first proposed over a decade ago, involves continuous ultrafiltration from the blood stream followed by cleansing of the filtrate, with subsequent return to the body. Thus, the system is completely self-contained and portable. During recent preclinical trials on nephrectomized canines, HFMS was better than hemodialysis (HD) in several important ways. First, the removal or clearance of middle molecules was better with 0.34 m2 HFMS than with 1 m2 HD. Significant phosphate clearance was achieved, and the removal rate for creatinine was the same as that for urea. This uniform clearance extends to even higher molecular weight solutes and could potentially result in improved patient response. It mimics the real kidney, whereas membrane-limited dialysis undergoes a logarithmic decrease of clearance with molecular weight. This is due to the fact that solute transport through the membrane involves solution into its matrix followed by diffusion, and solute diffusivity decreases with molecular volume. In order to achieve this potential for hemofiltration-based systems, however, there are stringent requirements on both the membrane and the plasma proteins allowed to accumulate on the membrane surface.

Original languageEnglish (US)
Pages (from-to)6-7
Number of pages2
JournalArtificial Organs
Volume3
Issue number1
StatePublished - 1979

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Artificial Kidneys
Hemofiltration
Membranes
Renal Dialysis
Molecular Weight
Molecular weight
Solute transport
Dialysis
Ultrafiltration
Urea
Canidae
Blood Proteins
Creatinine
Membrane Proteins
Phosphates
Blood
Proteins
Kidney
Plasmas
Molecules

ASJC Scopus subject areas

  • Biophysics

Cite this

Present status of the hemofiltration/molecular separation artificial kidney. / Dorson, W. J.; Pizziconi, Vincent.

In: Artificial Organs, Vol. 3, No. 1, 1979, p. 6-7.

Research output: Contribution to journalArticle

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