TY - JOUR
T1 - Presence of natural killer cells in specific-pathogen-free chickens
AU - Sharma, J. M.
AU - Coulson, B. D.
PY - 1979/8
Y1 - 1979/8
N2 - Spleen cells of normal specific-pathogen-free N, P, and 15 × 7 chickens were cytotoxic in vitro for target cells of Marek’s disease lymphoma line MSB-1. The natural killer (NK) cell activity, best expressed in chickens over 7 weeks old, varied among several genetic lines of chickens tested. The NK cells were thermolabile, and incubation of the cells at 37° C for 30–60 minutes resulted in substantial loss of cytotoxicity. The specificity of NK effector cells was directed against common antigen(s) on tumor cell lines of diverse origin but not on normal adult or embryonic cells.
AB - Spleen cells of normal specific-pathogen-free N, P, and 15 × 7 chickens were cytotoxic in vitro for target cells of Marek’s disease lymphoma line MSB-1. The natural killer (NK) cell activity, best expressed in chickens over 7 weeks old, varied among several genetic lines of chickens tested. The NK cells were thermolabile, and incubation of the cells at 37° C for 30–60 minutes resulted in substantial loss of cytotoxicity. The specificity of NK effector cells was directed against common antigen(s) on tumor cell lines of diverse origin but not on normal adult or embryonic cells.
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U2 - 10.1093/jnci/63.2.527
DO - 10.1093/jnci/63.2.527
M3 - Article
C2 - 156805
AN - SCOPUS:0018705977
SN - 0027-8874
VL - 63
SP - 527
EP - 531
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 2
ER -