Presence of natural killer cells in specific-pathogen-free chickens

J. M. Sharma, B. Coulson d.

Research output: Contribution to journalArticle

47 Scopus citations


Spleen cells of normal specific-pathogen-free N, P, and 15x7 chickens were cytotoxic in vitro for target cells of Marek's disease lymphoma line MSB-1. The natural killer (NK) cell activity, best expressed in chickens over 7 weeks old, varied among several genetic lines of chickens tested. The NK cells were thermolabile, and incubation of the cells at 37°C for 30-60 minutes resulted in substantial loss of cytotoxicity. The specificity of NK effector cells was directed against common antigen(s) on tumor cell lines of diverse origin but not on normal adult or embryonic cells.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalJournal of the National Cancer Institute
Issue number2
Publication statusPublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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