Predictability modulates human brain response to reward

Gregory S. Berns, Samuel McClure, Giuseppe Pagnoni, P. Read Montague

Research output: Contribution to journalArticle

478 Citations (Scopus)

Abstract

Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.

Original languageEnglish (US)
Pages (from-to)2793-2798
Number of pages6
JournalJournal of Neuroscience
Volume21
Issue number8
StatePublished - Apr 15 2001
Externally publishedYes

Fingerprint

Reward
Brain
Water
Nucleus Accumbens
Prefrontal Cortex
Human Activities
Magnetic Resonance Imaging
Food
Pharmaceutical Preparations

Keywords

  • Dopamine
  • fMRI
  • Neural network
  • Nucleus accumbens
  • Reinforcement
  • Reward
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Berns, G. S., McClure, S., Pagnoni, G., & Montague, P. R. (2001). Predictability modulates human brain response to reward. Journal of Neuroscience, 21(8), 2793-2798.

Predictability modulates human brain response to reward. / Berns, Gregory S.; McClure, Samuel; Pagnoni, Giuseppe; Montague, P. Read.

In: Journal of Neuroscience, Vol. 21, No. 8, 15.04.2001, p. 2793-2798.

Research output: Contribution to journalArticle

Berns, GS, McClure, S, Pagnoni, G & Montague, PR 2001, 'Predictability modulates human brain response to reward', Journal of Neuroscience, vol. 21, no. 8, pp. 2793-2798.
Berns GS, McClure S, Pagnoni G, Montague PR. Predictability modulates human brain response to reward. Journal of Neuroscience. 2001 Apr 15;21(8):2793-2798.
Berns, Gregory S. ; McClure, Samuel ; Pagnoni, Giuseppe ; Montague, P. Read. / Predictability modulates human brain response to reward. In: Journal of Neuroscience. 2001 ; Vol. 21, No. 8. pp. 2793-2798.
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