Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins

Guilherme M. Puga, Christian Meyer, Sarah Everman, Lawrence J. Mandarino, Christos Katsanos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the elderly, the rise in postprandial plasma triglyceride (TG) concentrations is increased, contributing to their increased risk of cardiovascular disease. We sought to determine the incorporation of ingested fat (whipping cream enriched with [1,1,1-13C]triolein) into plasma lipids during the postprandial period in six healthy elderly (67 ± 1 yr old) and six healthy young (23 ± 2 yr old) subjects. Blood and expired air samples were taken before and at 2-h intervals during the 8-h postprandial period. As expected, the area under the curve of postprandial plasma TG concentrations was larger in the elderly compared with the young subjects (152 ± 38 vs. 66 ± 27 mg·dl-1·h, P ± 0.05). The incorporation of [13C]oleate in plasma free fatty acids (FFAs) and TG of the small (Sf = 20-400) triglyceride-rich lipoprotein (TRL) fraction was significantly higher in the elderly compared with the young subjects, resulting in increased postprandial contributions of the ingested lipid to plasma FFAs (41 ± 3 vs. 26 ± 6%, P ± 0.05) and the small TRL fraction (36 ± 5 vs. 21 ± 3%, P ± 0.05) in elderly. Plasma apoB-100 concentration was higher, whereas the rate of oxidation of the ingested lipid was lower (P < 0.05) in the elderly. We conclude that increased postprandial lipemia in the elderly involves increased contribution of ingested lipid to the plasma small TRLs. This appears to be driven at least in part by increased appearance of the ingested fat as plasma FFA and increased availability of apo B-100 lipoproteins in the elderly.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume301
Issue number2
DOIs
StatePublished - Aug 2011

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Hyperlipidemias
Nonesterified Fatty Acids
Lipoproteins
Triglycerides
Fats
Postprandial Period
Apolipoprotein B-100
Lipids
Triolein
Oleic Acid
Area Under Curve
Cardiovascular Diseases
Air

Keywords

  • Aging
  • Chylomicrons
  • Spillover
  • Stable isotope tracers
  • Very low-density lipoprotein

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism

Cite this

Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins. / Puga, Guilherme M.; Meyer, Christian; Everman, Sarah; Mandarino, Lawrence J.; Katsanos, Christos.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 301, No. 2, 08.2011.

Research output: Contribution to journalArticle

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abstract = "In the elderly, the rise in postprandial plasma triglyceride (TG) concentrations is increased, contributing to their increased risk of cardiovascular disease. We sought to determine the incorporation of ingested fat (whipping cream enriched with [1,1,1-13C]triolein) into plasma lipids during the postprandial period in six healthy elderly (67 ± 1 yr old) and six healthy young (23 ± 2 yr old) subjects. Blood and expired air samples were taken before and at 2-h intervals during the 8-h postprandial period. As expected, the area under the curve of postprandial plasma TG concentrations was larger in the elderly compared with the young subjects (152 ± 38 vs. 66 ± 27 mg·dl-1·h, P ± 0.05). The incorporation of [13C]oleate in plasma free fatty acids (FFAs) and TG of the small (Sf = 20-400) triglyceride-rich lipoprotein (TRL) fraction was significantly higher in the elderly compared with the young subjects, resulting in increased postprandial contributions of the ingested lipid to plasma FFAs (41 ± 3 vs. 26 ± 6{\%}, P ± 0.05) and the small TRL fraction (36 ± 5 vs. 21 ± 3{\%}, P ± 0.05) in elderly. Plasma apoB-100 concentration was higher, whereas the rate of oxidation of the ingested lipid was lower (P < 0.05) in the elderly. We conclude that increased postprandial lipemia in the elderly involves increased contribution of ingested lipid to the plasma small TRLs. This appears to be driven at least in part by increased appearance of the ingested fat as plasma FFA and increased availability of apo B-100 lipoproteins in the elderly.",
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