Polynucleotide recognition and strand scission by Fe-bleomycin

Barbara J. Carter, Kalakota S. Reddy, Sidney Hecht

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.

Original languageEnglish (US)
Pages (from-to)2463-2474
Number of pages12
JournalTetrahedron
Volume47
Issue number14-15
DOIs
StatePublished - 1991
Externally publishedYes

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Polynucleotides
Bleomycin
RNA
DNA
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Polynucleotide recognition and strand scission by Fe-bleomycin. / Carter, Barbara J.; Reddy, Kalakota S.; Hecht, Sidney.

In: Tetrahedron, Vol. 47, No. 14-15, 1991, p. 2463-2474.

Research output: Contribution to journalArticle

Carter, Barbara J. ; Reddy, Kalakota S. ; Hecht, Sidney. / Polynucleotide recognition and strand scission by Fe-bleomycin. In: Tetrahedron. 1991 ; Vol. 47, No. 14-15. pp. 2463-2474.
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