Polynucleotide recognition and strand scission by Fe-bleomycin

Barbara J. Carter; Kalakota S. Reddy; Sidney M. Hecht

doi:10.1016/S0040-4020(01)81781-6

Polynucleotide recognition and strand scission by Fe-bleomycin

Barbara J. Carter, Kalakota S. Reddy, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.

Original language	English (US)
Pages (from-to)	2463-2474
Number of pages	12
Journal	Tetrahedron
Volume	47
Issue number	14-15
DOIs	https://doi.org/10.1016/S0040-4020(01)81781-6
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(01)81781-6

Cite this

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title = "Polynucleotide recognition and strand scission by Fe-bleomycin",

abstract = "The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.",

author = "Carter, {Barbara J.} and Reddy, {Kalakota S.} and Hecht, {Sidney M.}",

year = "1991",

doi = "10.1016/S0040-4020(01)81781-6",

language = "English (US)",

volume = "47",

pages = "2463--2474",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "14-15",

}

TY - JOUR

T1 - Polynucleotide recognition and strand scission by Fe-bleomycin

AU - Carter, Barbara J.

AU - Reddy, Kalakota S.

AU - Hecht, Sidney M.

PY - 1991

Y1 - 1991

N2 - The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.

AB - The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.

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U2 - 10.1016/S0040-4020(01)81781-6

DO - 10.1016/S0040-4020(01)81781-6

M3 - Article

AN - SCOPUS:17144443312

SN - 0040-4020

VL - 47

SP - 2463

EP - 2474

JO - Tetrahedron

JF - Tetrahedron

IS - 14-15

ER -

Polynucleotide recognition and strand scission by Fe-bleomycin

Abstract

ASJC Scopus subject areas

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