Polynucleotide recognition and strand scission by Fe-bleomycin

Barbara J. Carter, Kalakota S. Reddy, Sidney M. Hecht

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The structural basis of sequence-selective DNA recognition by Fe-bleomycin (Fe-BLM) has been studied by the use of BLM congeners in which the two functional domains are separated by spacers of variable length. Fe-bleomycin has also been shown to recognize and cleave RNA, which may constitute a new target of therapeutic importance for BLM.

Original languageEnglish (US)
Pages (from-to)2463-2474
Number of pages12
JournalTetrahedron
Volume47
Issue number14-15
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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