Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

Ya Ming Xu, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

Original languageEnglish (US)
Pages (from-to)657-659
Number of pages3
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number3
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Keywords

  • Dysidea
  • Polybrominated diphenyl ethers
  • Sponge
  • Tie2 kinase inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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