Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

Ya Ming Xu; Randall K. Johnson; Sidney M. Hecht

doi:10.1016/j.bmc.2004.10.061

Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

Ya Ming Xu, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

Original language	English (US)
Pages (from-to)	657-659
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.bmc.2004.10.061
State	Published - Feb 1 2005
Externally published	Yes

Keywords

Dysidea
Polybrominated diphenyl ethers
Sponge
Tie2 kinase inhibitor

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2004.10.061

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title = "Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase",

abstract = "Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.",

keywords = "Dysidea, Polybrominated diphenyl ethers, Sponge, Tie2 kinase inhibitor",

author = "Xu, {Ya Ming} and Johnson, {Randall K.} and Hecht, {Sidney M.}",

note = "Funding Information: This work was supported at the University of Virginia by NIH Research Grant CA50771 awarded by the National Cancer Institute.",

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doi = "10.1016/j.bmc.2004.10.061",

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T1 - Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

AU - Xu, Ya Ming

AU - Johnson, Randall K.

AU - Hecht, Sidney M.

N1 - Funding Information: This work was supported at the University of Virginia by NIH Research Grant CA50771 awarded by the National Cancer Institute.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

AB - Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

KW - Dysidea

KW - Polybrominated diphenyl ethers

KW - Sponge

KW - Tie2 kinase inhibitor

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ER -

Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

Abstract

Keywords

ASJC Scopus subject areas

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