Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

Ya Ming Xu, Randall K. Johnson, Sidney Hecht

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy) phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

Original languageEnglish (US)
Pages (from-to)657-659
Number of pages3
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number3
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Fingerprint

Dysidea
Halogenated Diphenyl Ethers
Bioassay
Porifera
Fractionation
Phenol
Biological Assay
Tumors
Phosphotransferases
Enzymes
Growth
Neoplasms
Therapeutics
3,5-dibromo-2-(2,4-dibromophenoxy)phenol

Keywords

  • Dysidea
  • Polybrominated diphenyl ethers
  • Sponge
  • Tie2 kinase inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase. / Xu, Ya Ming; Johnson, Randall K.; Hecht, Sidney.

In: Bioorganic and Medicinal Chemistry, Vol. 13, No. 3, 01.02.2005, p. 657-659.

Research output: Contribution to journalArticle

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