Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011

Lawrence Steinman, Robert C. Axtell, Donald Barbieri, Roopa Bhat, Sara E. Brownell, Brigit A. De Jong, Shannon E. Dunn, Jacqueline L. Grant, May H. Han, Peggy P. Ho, Hedwich F. Kuipers, Michael P. Kurnellas, Shalina S. Ousman, Jonathan B. Rothbard

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Four questions were posed about multiple sclerosis (MS) at the 2011 Charcot Lecture, Oct. 22, 2011. 1. The Male/Female Disparity: Why are women developing MS so much more frequently than men? 2. Neuronal and Glial Protection: Are there guardian molecules that protect the nervous system in MS? 3. Predictive Medicine: With all the approved drugs, how can we rationally decide which one to use? 4. The Precise Scalpel vs. the Big Hammer for Therapy: Is antigen-specific therapy for demyelinating disease possible? To emphasize how our views on the pathogenesis and treatment of MS are evolving, and given the location of the talk in Amsterdam, Piet Mondrian's progressive interpretations of trees serve as a heuristic.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalMultiple Sclerosis Journal
Volume19
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

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Keywords

  • Charcot Lecture
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Steinman, L., Axtell, R. C., Barbieri, D., Bhat, R., Brownell, S. E., De Jong, B. A., Dunn, S. E., Grant, J. L., Han, M. H., Ho, P. P., Kuipers, H. F., Kurnellas, M. P., Ousman, S. S., & Rothbard, J. B. (2013). Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011. Multiple Sclerosis Journal, 19(1), 5-14. https://doi.org/10.1177/1352458512470730