Physical activity frequency and risk of incident stroke in a National US study of blacks and whites

Michelle N. McDonnell, Susan L. Hillier, Steven P. Hooker, Anh Le, Suzanne E. Judd, Virginia J. Howard

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background and Purpose - Regular physical activity (PA) is an important recommendation for stroke prevention. We compared the associations of self-reported PA with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Methods - REGARDS recruited 30 239 US blacks (42%) and whites, aged ≥45 years with follow-up every 6 months for stroke events. Excluding those with prior stroke, analysis involved 27 348 participants who reported their frequency of moderate to vigorous intensity PA at baseline according to 3 categories: none (physical inactivity), 1 to 3×, and ≥4× per week. Stroke and transient ischemic attack cases were identified during an average of 5.7 years of follow-up. Cox proportional hazards models were constructed to examine whether self-reported PA was associated with risk of incident stroke. Results - Physical inactivity was reported by 33% of participants and was associated with a hazard ratio of 1.20 (95% confidence intervals, 1.02-1.42; P=0.035). Adjustment for demographic and socioeconomic factors did not affect hazard ratio, but further adjustment for traditional stroke risk factors (diabetes mellitus, hypertension, body mass index, alcohol use, and smoking) partially attenuated this risk (hazard ratio, 1.14 [0.95-1.37]; P=0.17). There was no significant association between PA frequency and risk of stroke by sex groups, although there was a trend toward increased risk for men reporting PA 0 to 3× a week compared with ≥4× a week. Conclusions - Self-reported low PA frequency is associated with increased risk of incident stroke. Any effect of PA is likely to be mediated through reducing traditional risk factors.

Original languageEnglish (US)
Pages (from-to)2519-2524
Number of pages6
JournalStroke
Volume44
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Stroke
Exercise
hydroquinone
Transient Ischemic Attack
Proportional Hazards Models
Diabetes Mellitus
Body Mass Index
Smoking
Odds Ratio
Alcohols
Demography
Confidence Intervals
Hypertension

Keywords

  • Exercise
  • Stroke
  • Stroke prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

McDonnell, M. N., Hillier, S. L., Hooker, S. P., Le, A., Judd, S. E., & Howard, V. J. (2013). Physical activity frequency and risk of incident stroke in a National US study of blacks and whites. Stroke, 44(9), 2519-2524. https://doi.org/10.1161/STROKEAHA.113.001538

Physical activity frequency and risk of incident stroke in a National US study of blacks and whites. / McDonnell, Michelle N.; Hillier, Susan L.; Hooker, Steven P.; Le, Anh; Judd, Suzanne E.; Howard, Virginia J.

In: Stroke, Vol. 44, No. 9, 09.2013, p. 2519-2524.

Research output: Contribution to journalArticle

McDonnell, MN, Hillier, SL, Hooker, SP, Le, A, Judd, SE & Howard, VJ 2013, 'Physical activity frequency and risk of incident stroke in a National US study of blacks and whites', Stroke, vol. 44, no. 9, pp. 2519-2524. https://doi.org/10.1161/STROKEAHA.113.001538
McDonnell, Michelle N. ; Hillier, Susan L. ; Hooker, Steven P. ; Le, Anh ; Judd, Suzanne E. ; Howard, Virginia J. / Physical activity frequency and risk of incident stroke in a National US study of blacks and whites. In: Stroke. 2013 ; Vol. 44, No. 9. pp. 2519-2524.
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