Paranemic Crossover DNA: There and Back Again

Xing Wang, Arun Richard Chandrasekaran, Zhiyong Shen, Yoel P. Ohayon, Tong Wang, Megan E. Kizer, Ruojie Sha, Chengde Mao, Hao Yan, Xiaoping Zhang, Shiping Liao, Baoquan Ding, Banani Chakraborty, Natasha Jonoska, Dong Niu, Hongzhou Gu, Jie Chao, Xiang Gao, Yuhang Li, Tanashaya CiengshinNadrian C. Seeman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Over the past 35 years, DNA has been used to produce various nanometer-scale constructs, nanomechanical devices, and walkers. Construction of complex DNA nanostructures relies on the creation of rigid DNA motifs. Paranemic crossover (PX) DNA is one such motif that has played many roles in DNA nanotechnology. Specifically, PX cohesion has been used to connect topologically closed molecules, to assemble a three-dimensional object, and to create two-dimensional DNA crystals. Additionally, a sequence-dependent nanodevice based on conformational change between PX and its topoisomer, JX2, has been used in robust nanoscale assembly lines, as a key component in a DNA transducer, and to dictate polymer assembly. Furthermore, the PX motif has recently found a new role directly in basic biology, by possibly serving as the molecular structure for double-stranded DNA homology recognition, a prominent feature of molecular biology and essential for many crucial biological processes. This review discusses the many attributes and usages of PX-DNA-its design, characteristics, applications, and potential biological relevance-and aims to accelerate the understanding of PX-DNA motif in its many roles and manifestations.

Original languageEnglish (US)
Pages (from-to)6273-6289
Number of pages17
JournalChemical reviews
Volume119
Issue number10
DOIs
StatePublished - May 22 2019

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DNA
Molecular biology
Nanotechnology
Molecular structure
Transducers
Nanostructures
Polymers
Crystals
Molecules

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Wang, X., Chandrasekaran, A. R., Shen, Z., Ohayon, Y. P., Wang, T., Kizer, M. E., ... Seeman, N. C. (2019). Paranemic Crossover DNA: There and Back Again. Chemical reviews, 119(10), 6273-6289. https://doi.org/10.1021/acs.chemrev.8b00207

Paranemic Crossover DNA : There and Back Again. / Wang, Xing; Chandrasekaran, Arun Richard; Shen, Zhiyong; Ohayon, Yoel P.; Wang, Tong; Kizer, Megan E.; Sha, Ruojie; Mao, Chengde; Yan, Hao; Zhang, Xiaoping; Liao, Shiping; Ding, Baoquan; Chakraborty, Banani; Jonoska, Natasha; Niu, Dong; Gu, Hongzhou; Chao, Jie; Gao, Xiang; Li, Yuhang; Ciengshin, Tanashaya; Seeman, Nadrian C.

In: Chemical reviews, Vol. 119, No. 10, 22.05.2019, p. 6273-6289.

Research output: Contribution to journalArticle

Wang, X, Chandrasekaran, AR, Shen, Z, Ohayon, YP, Wang, T, Kizer, ME, Sha, R, Mao, C, Yan, H, Zhang, X, Liao, S, Ding, B, Chakraborty, B, Jonoska, N, Niu, D, Gu, H, Chao, J, Gao, X, Li, Y, Ciengshin, T & Seeman, NC 2019, 'Paranemic Crossover DNA: There and Back Again', Chemical reviews, vol. 119, no. 10, pp. 6273-6289. https://doi.org/10.1021/acs.chemrev.8b00207
Wang X, Chandrasekaran AR, Shen Z, Ohayon YP, Wang T, Kizer ME et al. Paranemic Crossover DNA: There and Back Again. Chemical reviews. 2019 May 22;119(10):6273-6289. https://doi.org/10.1021/acs.chemrev.8b00207
Wang, Xing ; Chandrasekaran, Arun Richard ; Shen, Zhiyong ; Ohayon, Yoel P. ; Wang, Tong ; Kizer, Megan E. ; Sha, Ruojie ; Mao, Chengde ; Yan, Hao ; Zhang, Xiaoping ; Liao, Shiping ; Ding, Baoquan ; Chakraborty, Banani ; Jonoska, Natasha ; Niu, Dong ; Gu, Hongzhou ; Chao, Jie ; Gao, Xiang ; Li, Yuhang ; Ciengshin, Tanashaya ; Seeman, Nadrian C. / Paranemic Crossover DNA : There and Back Again. In: Chemical reviews. 2019 ; Vol. 119, No. 10. pp. 6273-6289.
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