Abstract
Phenylsilatrane analogues containing reactive amino, bromo, boronic ester, and alkynyl functional groups for coupling reactions have been prepared. Pinacol boronic ester and ethynyl analogues were synthesized from 4- bromophenylsilatrane by palladium catalyzed reactions. The silatrane functional group was shown to be stable during the palladium catalysis procedures and silica-gel purification, making the molecules amenable to further synthetic manipulation. The described phenylsilatranes are useful building blocks for forming more complex organosilatrane species.
Original language | English (US) |
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Pages (from-to) | 1062-1064 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 5 |
DOIs | |
State | Published - Jan 29 2014 |
Keywords
- Alkyne
- Amino
- Boronic ester
- Cross-coupling
- Silatrane
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry