Organic Hyperbolic Material Assisted Illumination Nanoscopy

Yeon Ui Lee, Clara Posner, Zhaoyu Nie, Junxiang Zhao, Shilong Li, Steven Edward Bopp, Gde Bimananda Mahardika Wisna, Jeongho Ha, Chengyu Song, Jin Zhang, Sui Yang, Xiang Zhang, Zhaowei Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Resolution capability of the linear structured illumination microscopy (SIM) plays a key role in its applications in physics, medicine, biology, and life science. Many advanced methodologies have been developed to extend the resolution of structured illumination by using subdiffraction-limited optical excitation patterns. However, obtaining SIM images with a resolution beyond 40 nm at visible frequency remains as an insurmountable obstacle due to the intrinsic limitation of spatial frequency bandwidth of the involved materials and the complexity of the illumination system. Here, a low-loss natural organic hyperbolic material (OHM) that can support record high spatial-frequency modes beyond 50k0, i.e., effective refractive index larger than 50, at visible frequencies is reported. OHM-based speckle structured illumination microscopy demonstrates imaging resolution at 30 nm scales with enhanced fluorophore photostability, biocompatibility, easy to use and low cost. This study will open up a new route in super-resolution microscopy by utilizing OHM films for various applications including bioimaging and sensing.

Original languageEnglish (US)
Article number2102230
JournalAdvanced Science
Volume8
Issue number22
DOIs
StatePublished - Nov 17 2021
Externally publishedYes

Keywords

  • bioimaging
  • organic hyperbolic materials
  • poly(3-hexylthiophenes)
  • structured illumination microscopy
  • super-resolution microscopy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

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