Opioid κ-receptor agonists suppress sexual behaviors in male rough-skinned newts (Taricha granulosa)

Pierre Deviche, Frank L. Moore

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Four experiments were performed to evaluate a possible opioid involvement in the regulation of sexual behavior (amplectic clasping of a female) in intact adult male rough-skinned newts (Taricha granulosa) during the breeding season. It was found that an ip injection of bremazocine, a κ-receptor opiate agonist, can markedly reduce sexual activity and that an ip injection of naloxone can reverse this inhibition in a dose-dependent fashion. In contrast, in male newts that were sexually inactive before treatment, injections of naloxone failed to induce sexual behavior, suggesting that opioid mechanisms do not normally exert a tonic inhibition of amphibian sexual behavior. In addition, an injection of ethylketocyclazocine (another κ-receptor agonist), but not morphine (a μ-receptor agonist) suppressed sexual behaviors of male newts. These results indicate that opioid mechanisms that include κ-type opioid receptors may contribute to the regulation of sexual behavior in nonmammalian vertebrates.

Original languageEnglish (US)
Pages (from-to)371-383
Number of pages13
JournalHormones and Behavior
Volume21
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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Salamandridae
Opioid Receptors
Sexual Behavior
Opioid Analgesics
Injections
Naloxone
Ethylketocyclazocine
Amphibians
Morphine
Breeding
Vertebrates

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Opioid κ-receptor agonists suppress sexual behaviors in male rough-skinned newts (Taricha granulosa). / Deviche, Pierre; Moore, Frank L.

In: Hormones and Behavior, Vol. 21, No. 3, 1987, p. 371-383.

Research output: Contribution to journalArticle

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