Opiate antagonists stereoselectively attenuate the consumption of food but not of water by pigeons

Pierre Deviche, Angelika Wohland

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Three experiments were performed to evaluate the influence of the two opiate antagonists, naloxone HCl (NAL) and Mr 2266, on the ingestive behavior of domestic pigeons. In the first and second experiments, these drugs were administered at 3 doses (0.25, 1 and 4 mg) to non-deprived and to 24 hr-fasted pigeons, respectively. Measure of the food and water consumption of the birds for up to 6 hrs post-injection revealed that as compared to control values, administration of both antagonists attenuated feeding without reducing drinking. Administration of both drugs produced a rather similar anorexic effect, with the difference that Mr 2266 tended to decrease the food intake for a longer period of time than did NAL. In the third experiment, the food consumption of fasted pigeons was reduced by the injection of Mr 2266, but not of its (+) stereoisomer Mr 2267, showing that the behavioral influence of Mr 2266 is stereoselective. Confronted with other studies, these results suggest that in pigeons, opiate receptors participate in the regulation of the food consumption without playing a major role in the control of the water intake.

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume21
Issue number4
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Keywords

  • Drinking
  • Feeding
  • Ingestive behavior
  • Mr 2266
  • Naloxone
  • Opiate antagonists
  • Pigeons
  • Stereoselectivity

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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