Ondrej Krivanek's early scientific research

    Research output: Contribution to journalArticle

    Abstract

    In 1806, Humphrey Davey said that "nothing promotes the advancement of science so much as a new instrument". This paper reviews some of the lesser-known achievements of Ondrej's early career, and reminds us of the level of performance of instruments in those days, in order to appreciate how great has been the progress in instrumentation, much of it due to Ondrej and his leadership, since then. Some new results in the field of EELS are described, including extraction of the time-dependence of the dielectric response (with better time resolution than an X-ray free electron laser (XFEL)) from Nion EELS data. An approximation for atomic-resolution imaging which includes multiple scattering effects is given for biological samples, for use with aberration-corrected instruments when these become needed at the higher beam energies required to preserve the projection approximation, on which the 3D merging of single-particle cryo-EM images is based. We also discuss the requirements for out-running radiation damage using pulsed electron beams, a worthy final challenge for OLK.

    Original languageEnglish (US)
    JournalUltramicroscopy
    DOIs
    StateAccepted/In press - Oct 2 2016

    Fingerprint

    Electron energy loss spectroscopy
    X ray lasers
    Multiple scattering
    Free electron lasers
    Radiation damage
    Aberrations
    leadership
    Merging
    Electron beams
    approximation
    radiation damage
    free electron lasers
    time dependence
    Imaging techniques
    aberration
    projection
    electron beams
    requirements
    scattering
    x rays

    Keywords

    • Energy-loss spectroscopy cryo-EM
    • Radiation damage

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Instrumentation

    Cite this

    Ondrej Krivanek's early scientific research. / Spence, John.

    In: Ultramicroscopy, 02.10.2016.

    Research output: Contribution to journalArticle

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