Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants

Jiao Li, Donghong Liu, Xiaojun Tian, Shigenobu Koseki, Shiguo Chen, Xingqian Ye, Tian Ding

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious bacterial pathogen that induces high mortality and morbidity. Due to the emergence of multiple resistance, antibiotic treatments are rapidly becoming ineffective for the related infections. Natural products, especially those derived from plants, have been proven to be effective agents with unique antibacterial properties through different mechanisms. This review interprets the resistance mechanisms of MRSA with the aim to conquer public health threat. Further, recent researches about plant antimicrobials that showed remarkable antibacterial activity against MRSA are recorded, including the crude plant extracts and purified plant-derived bioactive compounds. Novel anti-MRSA modalities of plant antimicrobials such as alteration in efflux pump, inhibition of pyruvate kinase, and disturbance of quorum sensing in MRSA are also summarized which may be promising alternatives to antibacterial drug development in future.

Original languageEnglish (US)
Pages (from-to)S153-S161
JournalCritical reviews in food science and nutrition
Volume59
DOIs
StatePublished - Jan 1 2019

Fingerprint

Plant extracts
Public health
Pathogens
Antibiotics
Methicillin-Resistant Staphylococcus aureus
Pumps
anti-infective agents
Quorum Sensing
pyruvate kinase
quorum sensing
Pyruvate Kinase
antibacterial properties
Plant Extracts
Phytochemicals
Microbial Drug Resistance
Biological Products
Complex Mixtures
resistance mechanisms
plant extracts
antibiotic resistance

Keywords

  • efflux pump
  • MRSA
  • plant antimicrobials
  • pyruvate kinase
  • quorum sensing

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants. / Li, Jiao; Liu, Donghong; Tian, Xiaojun; Koseki, Shigenobu; Chen, Shiguo; Ye, Xingqian; Ding, Tian.

In: Critical reviews in food science and nutrition, Vol. 59, 01.01.2019, p. S153-S161.

Research output: Contribution to journalArticle

Li, Jiao ; Liu, Donghong ; Tian, Xiaojun ; Koseki, Shigenobu ; Chen, Shiguo ; Ye, Xingqian ; Ding, Tian. / Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants. In: Critical reviews in food science and nutrition. 2019 ; Vol. 59. pp. S153-S161.
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