Notch pathway genes are expressed in mammalian ovarian follicles

Joshua Johnson, Tamara Espinoza, Robert W. McGaughey, Alan Rawls, Jeanne Wilson-Rawls

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Folliculogenesis is the process of development of ovarian follicles that ultimately results in the release of fertilizable oocytes at ovulation. This is a complex program that involves the proliferation and differentiation of granulosa cells. Granulosa cells are necessary for follicle growth and support the oocyte during folliculogenesis. Genes that regulate the proliferation and differentiation of granulosa cells are beginning to be elucidated. In this study, the expression patterns of Notch receptor genes and their ligands, which have been shown to regulate cell-fate decisions in many systems during development, were examined in the mammalian ovary. In situ hybridization data showed that Notch2, Notch3, and Jagged2 were expressed in an overlapping pattern in the granulosa cells of developing follicles. Jagged1 was expressed in oocytes exclusively. Downstream target genes of Notch also were expressed in granulosa cells. These data implicate the Notch signaling pathway in the regulation of mammalian folliculogenesis.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalMechanisms of Development
Volume109
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Ovarian Follicle
Granulosa Cells
Oocytes
Genes
Notch Receptors
Ovulation
In Situ Hybridization
Ovary
Ligands
Growth

Keywords

  • Follicle
  • Granulosa
  • Jagged
  • Notch
  • Ovary

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Notch pathway genes are expressed in mammalian ovarian follicles. / Johnson, Joshua; Espinoza, Tamara; McGaughey, Robert W.; Rawls, Alan; Wilson-Rawls, Jeanne.

In: Mechanisms of Development, Vol. 109, No. 2, 2001, p. 355-361.

Research output: Contribution to journalArticle

Johnson, Joshua ; Espinoza, Tamara ; McGaughey, Robert W. ; Rawls, Alan ; Wilson-Rawls, Jeanne. / Notch pathway genes are expressed in mammalian ovarian follicles. In: Mechanisms of Development. 2001 ; Vol. 109, No. 2. pp. 355-361.
@article{7625fb130665415696bbe7b919c020fb,
title = "Notch pathway genes are expressed in mammalian ovarian follicles",
abstract = "Folliculogenesis is the process of development of ovarian follicles that ultimately results in the release of fertilizable oocytes at ovulation. This is a complex program that involves the proliferation and differentiation of granulosa cells. Granulosa cells are necessary for follicle growth and support the oocyte during folliculogenesis. Genes that regulate the proliferation and differentiation of granulosa cells are beginning to be elucidated. In this study, the expression patterns of Notch receptor genes and their ligands, which have been shown to regulate cell-fate decisions in many systems during development, were examined in the mammalian ovary. In situ hybridization data showed that Notch2, Notch3, and Jagged2 were expressed in an overlapping pattern in the granulosa cells of developing follicles. Jagged1 was expressed in oocytes exclusively. Downstream target genes of Notch also were expressed in granulosa cells. These data implicate the Notch signaling pathway in the regulation of mammalian folliculogenesis.",
keywords = "Follicle, Granulosa, Jagged, Notch, Ovary",
author = "Joshua Johnson and Tamara Espinoza and McGaughey, {Robert W.} and Alan Rawls and Jeanne Wilson-Rawls",
year = "2001",
doi = "10.1016/S0925-4773(01)00523-8",
language = "English (US)",
volume = "109",
pages = "355--361",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Notch pathway genes are expressed in mammalian ovarian follicles

AU - Johnson, Joshua

AU - Espinoza, Tamara

AU - McGaughey, Robert W.

AU - Rawls, Alan

AU - Wilson-Rawls, Jeanne

PY - 2001

Y1 - 2001

N2 - Folliculogenesis is the process of development of ovarian follicles that ultimately results in the release of fertilizable oocytes at ovulation. This is a complex program that involves the proliferation and differentiation of granulosa cells. Granulosa cells are necessary for follicle growth and support the oocyte during folliculogenesis. Genes that regulate the proliferation and differentiation of granulosa cells are beginning to be elucidated. In this study, the expression patterns of Notch receptor genes and their ligands, which have been shown to regulate cell-fate decisions in many systems during development, were examined in the mammalian ovary. In situ hybridization data showed that Notch2, Notch3, and Jagged2 were expressed in an overlapping pattern in the granulosa cells of developing follicles. Jagged1 was expressed in oocytes exclusively. Downstream target genes of Notch also were expressed in granulosa cells. These data implicate the Notch signaling pathway in the regulation of mammalian folliculogenesis.

AB - Folliculogenesis is the process of development of ovarian follicles that ultimately results in the release of fertilizable oocytes at ovulation. This is a complex program that involves the proliferation and differentiation of granulosa cells. Granulosa cells are necessary for follicle growth and support the oocyte during folliculogenesis. Genes that regulate the proliferation and differentiation of granulosa cells are beginning to be elucidated. In this study, the expression patterns of Notch receptor genes and their ligands, which have been shown to regulate cell-fate decisions in many systems during development, were examined in the mammalian ovary. In situ hybridization data showed that Notch2, Notch3, and Jagged2 were expressed in an overlapping pattern in the granulosa cells of developing follicles. Jagged1 was expressed in oocytes exclusively. Downstream target genes of Notch also were expressed in granulosa cells. These data implicate the Notch signaling pathway in the regulation of mammalian folliculogenesis.

KW - Follicle

KW - Granulosa

KW - Jagged

KW - Notch

KW - Ovary

UR - http://www.scopus.com/inward/record.url?scp=0035193414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035193414&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(01)00523-8

DO - 10.1016/S0925-4773(01)00523-8

M3 - Article

C2 - 11731249

AN - SCOPUS:0035193414

VL - 109

SP - 355

EP - 361

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 2

ER -