Noninvasive tear stress sensing

Jeffrey LaBelle (Inventor)

Research output: Patent

Abstract

Chronic stress has been widely implicated in a plethora of lethal and life-altering diseases including diabetes, heart attacks, depression, Alzheimer's and osteoporosis. Thus, there is great interest in monitoring stress levels in the population. Stress has both biochemical and physiological effects on the body that can be quantified in bodily fluids. Currently, blood is the standard diagnostic testing fluid, but tears, saliva, and serum are being investigated as possible alternatives due to the problems associated with drawing blood. However, the stress hormones that are currently measured in blood, such as glucocorticoids and catecholamines, do not have high enough physiological concentration in these alternative fluids, making precise measurements a technical challenge. Researchers at Arizona State University have developed a screen printed electrochemical sensor that can obtain a tear sample via a novel microfluidic capture system. This system can detect stress/trauma biomarkers that are present in tears, such as cortisol, with femtomolar sensitivity. Mesoporous carbon inks encapsulate the recognition elements for the stress/trauma biomarkers, blocking interferents and providing better rest results. This system has been tested with cortisol, and the assay is highly reproducible and can detect very low levels. This sensor enables a highly reproducible and ultralow level of detection in a label-free and rapid response configuration. And, by utilizing tears, this novel device provides a simple and painless means for detecting stress biomarkers levels in the body. Potential Applications Non-invasive monitoring of stress/trauma biomarkers (cortisol, glucose, lactate, lactoferrin, IgE, catecholamines, S100beta, neuron specific enolase, etc.): Sports medicine Military Law enforcement Emergency personnel Benefits and Advantages Rapid monitoring - 90 second detection Femtomolar sensitivity Label-free Noninvasive Point of care Highly reproducible Minimal background interference Quantitative measurements Dowload Original PDF For more information about the inventor(s) and their research, please see Dr. La Belle's laboratory webpage
Original languageEnglish (US)
StatePublished - Sep 4 2013

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Tears
Biomarkers
Hydrocortisone
Catecholamines
Wounds and Injuries
Point-of-Care Systems
Inventors
Law Enforcement
Sports Medicine
Ink
Lactoferrin
Microfluidics
Phosphopyruvate Hydratase
Saliva
Immunoglobulin E
Glucocorticoids
Osteoporosis
Lactic Acid
Emergencies
Carbon

Cite this

LaBelle, J. (2013). Noninvasive tear stress sensing.

Noninvasive tear stress sensing. / LaBelle, Jeffrey (Inventor).

Research output: Patent

LaBelle J, inventor. Noninvasive tear stress sensing. 2013 Sep 4.
LaBelle, Jeffrey (Inventor). / Noninvasive tear stress sensing.
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