Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing

Fernando F. Locatelli, Patricia C. Fernandez, Francis Villareal, Kerem Muezzinoglu, Ramon Huerta, C. Giovanni Galizia, Brian Smith

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task.

Original languageEnglish (US)
Pages (from-to)63-79
Number of pages17
JournalEuropean Journal of Neuroscience
Volume37
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Neuronal Plasticity
Neurons
Honey
Bees
Interneurons
Synapses
Calcium
Odorants

Keywords

  • Antennal lobe
  • Learning
  • Olfaction
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing. / Locatelli, Fernando F.; Fernandez, Patricia C.; Villareal, Francis; Muezzinoglu, Kerem; Huerta, Ramon; Galizia, C. Giovanni; Smith, Brian.

In: European Journal of Neuroscience, Vol. 37, No. 1, 01.2013, p. 63-79.

Research output: Contribution to journalArticle

Locatelli, Fernando F. ; Fernandez, Patricia C. ; Villareal, Francis ; Muezzinoglu, Kerem ; Huerta, Ramon ; Galizia, C. Giovanni ; Smith, Brian. / Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing. In: European Journal of Neuroscience. 2013 ; Vol. 37, No. 1. pp. 63-79.
@article{44faefbb2bff44389a69ca18d9ebdaed,
title = "Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing",
abstract = "Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task.",
keywords = "Antennal lobe, Learning, Olfaction, Plasticity",
author = "Locatelli, {Fernando F.} and Fernandez, {Patricia C.} and Francis Villareal and Kerem Muezzinoglu and Ramon Huerta and Galizia, {C. Giovanni} and Brian Smith",
year = "2013",
month = "1",
doi = "10.1111/ejn.12021",
language = "English (US)",
volume = "37",
pages = "63--79",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing

AU - Locatelli, Fernando F.

AU - Fernandez, Patricia C.

AU - Villareal, Francis

AU - Muezzinoglu, Kerem

AU - Huerta, Ramon

AU - Galizia, C. Giovanni

AU - Smith, Brian

PY - 2013/1

Y1 - 2013/1

N2 - Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task.

AB - Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task.

KW - Antennal lobe

KW - Learning

KW - Olfaction

KW - Plasticity

UR - http://www.scopus.com/inward/record.url?scp=84872136644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872136644&partnerID=8YFLogxK

U2 - 10.1111/ejn.12021

DO - 10.1111/ejn.12021

M3 - Article

C2 - 23167675

AN - SCOPUS:84872136644

VL - 37

SP - 63

EP - 79

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 1

ER -