Neuroprotective-neurotrophic effect of endogenous dehydroepiandrosterone sulfate during intense stress exposure

Marcus K. Taylor; Michael Stone; Heidemarie K. Laurent; Mitchell J. Rauh; Douglas A. Granger

doi:10.1016/j.steroids.2014.05.011

Neuroprotective-neurotrophic effect of endogenous dehydroepiandrosterone sulfate during intense stress exposure

Marcus K. Taylor, Michael Stone, Heidemarie K. Laurent, Mitchell J. Rauh, Douglas A. Granger

Psychology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational study was designed to examine neuroprotective-neurotrophic effects of DHEAS throughout intense stress exposure in healthy men and women. The study took place within a stressful 12-day military survival course. Utilizing a longitudinal cross-sectional repeated measures design, One hundred sixteen healthy active-duty military personnel (80% male) were studied before, during, and 24 h after the course. The dependent variable was the neurotrophin salivary nerve growth factor (sNGF). In terms of total hormone output, the effect of DHEAS on sNGF was mediated by testosterone. Unlike testosterone or cortisol, DHEAS reliably predicted sNGF at each time point, and change in DHEAS predicted change in sNGF across time points. Baseline DHEAS predicted total sNGF output across the stress trajectory. Consistent with preclinical as well as cross-sectional human research, this study demonstrates neuroprotective-neurotrophic effects of DHEAS in healthy men and women exposed to intense stress. Results are evaluated in relation to established criteria for causation.

Original language	English (US)
Pages (from-to)	54-58
Number of pages	5
Journal	Steroids
Volume	87
DOIs	https://doi.org/10.1016/j.steroids.2014.05.011
State	Published - Sep 2014

Keywords

Cortisol
DHEA sulfate
Nerve growth factor
Neurotrophin
Stress
Testosterone

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/j.steroids.2014.05.011

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@article{65f27d395e5d46d08f4f7f9f967feec2,

title = "Neuroprotective-neurotrophic effect of endogenous dehydroepiandrosterone sulfate during intense stress exposure",

abstract = "Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational study was designed to examine neuroprotective-neurotrophic effects of DHEAS throughout intense stress exposure in healthy men and women. The study took place within a stressful 12-day military survival course. Utilizing a longitudinal cross-sectional repeated measures design, One hundred sixteen healthy active-duty military personnel (80% male) were studied before, during, and 24 h after the course. The dependent variable was the neurotrophin salivary nerve growth factor (sNGF). In terms of total hormone output, the effect of DHEAS on sNGF was mediated by testosterone. Unlike testosterone or cortisol, DHEAS reliably predicted sNGF at each time point, and change in DHEAS predicted change in sNGF across time points. Baseline DHEAS predicted total sNGF output across the stress trajectory. Consistent with preclinical as well as cross-sectional human research, this study demonstrates neuroprotective-neurotrophic effects of DHEAS in healthy men and women exposed to intense stress. Results are evaluated in relation to established criteria for causation.",

keywords = "Cortisol, DHEA sulfate, Nerve growth factor, Neurotrophin, Stress, Testosterone",

author = "Taylor, {Marcus K.} and Michael Stone and Laurent, {Heidemarie K.} and Rauh, {Mitchell J.} and Granger, {Douglas A.}",

note = "Funding Information: This study was supported by a Grant from the Office of Naval Research, and the work was performed under work unit number 60124. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2011.0033). U.S. Government Work (17 USC 105). Not copyrighted in the U.S. ",

year = "2014",

month = sep,

doi = "10.1016/j.steroids.2014.05.011",

language = "English (US)",

volume = "87",

pages = "54--58",

journal = "Steroids",

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AU - Taylor, Marcus K.

AU - Stone, Michael

AU - Laurent, Heidemarie K.

AU - Rauh, Mitchell J.

AU - Granger, Douglas A.

N1 - Funding Information: This study was supported by a Grant from the Office of Naval Research, and the work was performed under work unit number 60124. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2011.0033). U.S. Government Work (17 USC 105). Not copyrighted in the U.S.

PY - 2014/9

Y1 - 2014/9

N2 - Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational study was designed to examine neuroprotective-neurotrophic effects of DHEAS throughout intense stress exposure in healthy men and women. The study took place within a stressful 12-day military survival course. Utilizing a longitudinal cross-sectional repeated measures design, One hundred sixteen healthy active-duty military personnel (80% male) were studied before, during, and 24 h after the course. The dependent variable was the neurotrophin salivary nerve growth factor (sNGF). In terms of total hormone output, the effect of DHEAS on sNGF was mediated by testosterone. Unlike testosterone or cortisol, DHEAS reliably predicted sNGF at each time point, and change in DHEAS predicted change in sNGF across time points. Baseline DHEAS predicted total sNGF output across the stress trajectory. Consistent with preclinical as well as cross-sectional human research, this study demonstrates neuroprotective-neurotrophic effects of DHEAS in healthy men and women exposed to intense stress. Results are evaluated in relation to established criteria for causation.

AB - Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational study was designed to examine neuroprotective-neurotrophic effects of DHEAS throughout intense stress exposure in healthy men and women. The study took place within a stressful 12-day military survival course. Utilizing a longitudinal cross-sectional repeated measures design, One hundred sixteen healthy active-duty military personnel (80% male) were studied before, during, and 24 h after the course. The dependent variable was the neurotrophin salivary nerve growth factor (sNGF). In terms of total hormone output, the effect of DHEAS on sNGF was mediated by testosterone. Unlike testosterone or cortisol, DHEAS reliably predicted sNGF at each time point, and change in DHEAS predicted change in sNGF across time points. Baseline DHEAS predicted total sNGF output across the stress trajectory. Consistent with preclinical as well as cross-sectional human research, this study demonstrates neuroprotective-neurotrophic effects of DHEAS in healthy men and women exposed to intense stress. Results are evaluated in relation to established criteria for causation.

KW - Cortisol

KW - DHEA sulfate

KW - Nerve growth factor

KW - Neurotrophin

KW - Stress

KW - Testosterone

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JO - Steroids

JF - Steroids

ER -

Neuroprotective-neurotrophic effect of endogenous dehydroepiandrosterone sulfate during intense stress exposure

Abstract

Keywords

ASJC Scopus subject areas

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