Neuronal development: SAD kinases make happy axons

Lei Xing; Jason M. Newbern; William D. Snider

doi:10.1016/j.cub.2013.07.073

Neuronal development: SAD kinases make happy axons

Lei Xing, Jason M. Newbern, William D. Snider

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.

Original language	English (US)
Pages (from-to)	R720-R723
Journal	Current Biology
Volume	23
Issue number	17
DOIs	https://doi.org/10.1016/j.cub.2013.07.073
State	Published - Sep 9 2013
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2013.07.073

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title = "Neuronal development: SAD kinases make happy axons",

abstract = "The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.",

author = "Lei Xing and Newbern, {Jason M.} and Snider, {William D.}",

year = "2013",

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doi = "10.1016/j.cub.2013.07.073",

language = "English (US)",

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T1 - Neuronal development

T2 - SAD kinases make happy axons

AU - Xing, Lei

AU - Newbern, Jason M.

AU - Snider, William D.

PY - 2013/9/9

Y1 - 2013/9/9

N2 - The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.

AB - The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.

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DO - 10.1016/j.cub.2013.07.073

M3 - Short survey

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VL - 23

SP - R720-R723

JO - Current Biology

JF - Current Biology

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ER -

Neuronal development: SAD kinases make happy axons

Abstract

ASJC Scopus subject areas

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