Neuronal development: SAD kinases make happy axons

Lei Xing, Jason M. Newbern, William D. Snider

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.

Original languageEnglish (US)
Pages (from-to)R720-R723
JournalCurrent Biology
Volume23
Issue number17
DOIs
StatePublished - Sep 9 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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