Neuromechanics: The Role of Tension in Neuronal Growth and Memory

Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi, Taher A. Saif

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Growing experimental evidence suggests that the mechanical micro-environment plays a role in growth and guidance of neurons. Recent studies have shown that mechanical tension plays a role in neuronal function, including neurotransmission and synaptic vesicle clustering. In this review, we discuss the role of mechanical tension in determining the structure and function of neurons and its implication in learning and memory. To interpret the mechanical behavior of neurons a simple mechanics model is proposed based on force generation by molecular motors on cytoskeletal elements. The review concludes by highlighting some unanswered questions in cellular neuromechanics.

Original languageEnglish (US)
Title of host publicationNano and Cell Mechanics: Fundamentals and Frontiers
PublisherJohn Wiley and Sons
Pages35-61
Number of pages27
ISBN (Print)9781118460399
DOIs
StatePublished - Dec 11 2012

Fingerprint

Neurons
Data storage equipment
Mechanics

Keywords

  • Cell mechanics
  • Learning
  • Mechanotransduction
  • Memory
  • Neuromechanics
  • Neuron function
  • Synaptic plasticity
  • Vesicle dynamics

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ahmed, W. W., Rajagopalan, J., Tofangchi, A., & Saif, T. A. (2012). Neuromechanics: The Role of Tension in Neuronal Growth and Memory. In Nano and Cell Mechanics: Fundamentals and Frontiers (pp. 35-61). John Wiley and Sons. https://doi.org/10.1002/9781118482568.ch3

Neuromechanics : The Role of Tension in Neuronal Growth and Memory. / Ahmed, Wylie W.; Rajagopalan, Jagannathan; Tofangchi, Alireza; Saif, Taher A.

Nano and Cell Mechanics: Fundamentals and Frontiers. John Wiley and Sons, 2012. p. 35-61.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ahmed, WW, Rajagopalan, J, Tofangchi, A & Saif, TA 2012, Neuromechanics: The Role of Tension in Neuronal Growth and Memory. in Nano and Cell Mechanics: Fundamentals and Frontiers. John Wiley and Sons, pp. 35-61. https://doi.org/10.1002/9781118482568.ch3
Ahmed WW, Rajagopalan J, Tofangchi A, Saif TA. Neuromechanics: The Role of Tension in Neuronal Growth and Memory. In Nano and Cell Mechanics: Fundamentals and Frontiers. John Wiley and Sons. 2012. p. 35-61 https://doi.org/10.1002/9781118482568.ch3
Ahmed, Wylie W. ; Rajagopalan, Jagannathan ; Tofangchi, Alireza ; Saif, Taher A. / Neuromechanics : The Role of Tension in Neuronal Growth and Memory. Nano and Cell Mechanics: Fundamentals and Frontiers. John Wiley and Sons, 2012. pp. 35-61
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