Neurochemical and neurostructural plasticity in alcoholism

Justin T. Gass, Michael Olive

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The behavioral manifestations of alcoholism are primarily attributable to the numerous and lasting adaptations that occur in the brain as a result of chronic heavy alcohol consumption. As will be reviewed here, these adaptations include alcohol-induced plasticity in chemical neurotransmission, density and morphology of dendritic spines, as well as neurodegeneration and cerebral atrophy. Within the context of these neuroadaptations that have been observed in both human and animal studies, we will discuss how these changes potentially contribute to the cognitive and behavioral dysfunctions that are hallmark features of alcoholism, as well as how they reveal novel potential pharmacological targets for the treatment of this disorder.

Original languageEnglish (US)
Pages (from-to)494-504
Number of pages11
JournalACS Chemical Neuroscience
Volume3
Issue number7
DOIs
StatePublished - Jul 18 2012

Fingerprint

Alcoholism
Plasticity
Alcohols
Dendritic Spines
Synaptic Transmission
Alcohol Drinking
Atrophy
Brain
Animals
Pharmacology
Cognitive Dysfunction

Keywords

  • Alcoholism
  • cerebral atrophy
  • dendritic spine
  • neural plasticity
  • neurochemistry
  • neurodegeneration
  • neurotransmission

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Cognitive Neuroscience

Cite this

Neurochemical and neurostructural plasticity in alcoholism. / Gass, Justin T.; Olive, Michael.

In: ACS Chemical Neuroscience, Vol. 3, No. 7, 18.07.2012, p. 494-504.

Research output: Contribution to journalArticle

@article{83aa0e26c70a4634870da1d1494c508e,
title = "Neurochemical and neurostructural plasticity in alcoholism",
abstract = "The behavioral manifestations of alcoholism are primarily attributable to the numerous and lasting adaptations that occur in the brain as a result of chronic heavy alcohol consumption. As will be reviewed here, these adaptations include alcohol-induced plasticity in chemical neurotransmission, density and morphology of dendritic spines, as well as neurodegeneration and cerebral atrophy. Within the context of these neuroadaptations that have been observed in both human and animal studies, we will discuss how these changes potentially contribute to the cognitive and behavioral dysfunctions that are hallmark features of alcoholism, as well as how they reveal novel potential pharmacological targets for the treatment of this disorder.",
keywords = "Alcoholism, cerebral atrophy, dendritic spine, neural plasticity, neurochemistry, neurodegeneration, neurotransmission",
author = "Gass, {Justin T.} and Michael Olive",
year = "2012",
month = "7",
day = "18",
doi = "10.1021/cn300013p",
language = "English (US)",
volume = "3",
pages = "494--504",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Neurochemical and neurostructural plasticity in alcoholism

AU - Gass, Justin T.

AU - Olive, Michael

PY - 2012/7/18

Y1 - 2012/7/18

N2 - The behavioral manifestations of alcoholism are primarily attributable to the numerous and lasting adaptations that occur in the brain as a result of chronic heavy alcohol consumption. As will be reviewed here, these adaptations include alcohol-induced plasticity in chemical neurotransmission, density and morphology of dendritic spines, as well as neurodegeneration and cerebral atrophy. Within the context of these neuroadaptations that have been observed in both human and animal studies, we will discuss how these changes potentially contribute to the cognitive and behavioral dysfunctions that are hallmark features of alcoholism, as well as how they reveal novel potential pharmacological targets for the treatment of this disorder.

AB - The behavioral manifestations of alcoholism are primarily attributable to the numerous and lasting adaptations that occur in the brain as a result of chronic heavy alcohol consumption. As will be reviewed here, these adaptations include alcohol-induced plasticity in chemical neurotransmission, density and morphology of dendritic spines, as well as neurodegeneration and cerebral atrophy. Within the context of these neuroadaptations that have been observed in both human and animal studies, we will discuss how these changes potentially contribute to the cognitive and behavioral dysfunctions that are hallmark features of alcoholism, as well as how they reveal novel potential pharmacological targets for the treatment of this disorder.

KW - Alcoholism

KW - cerebral atrophy

KW - dendritic spine

KW - neural plasticity

KW - neurochemistry

KW - neurodegeneration

KW - neurotransmission

UR - http://www.scopus.com/inward/record.url?scp=84863978002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863978002&partnerID=8YFLogxK

U2 - 10.1021/cn300013p

DO - 10.1021/cn300013p

M3 - Article

C2 - 22896799

AN - SCOPUS:84863978002

VL - 3

SP - 494

EP - 504

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 7

ER -