N-isopropylacrylamide-based copolymers with time-dependent LCST for a bioresorbable carrier

Bae Hoon Lee, Brent Vernon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To develop a new class of in situ-forming, injectable, and biodegradable polymeric biomaterials based on time-dependent lower critical solution temperature (LCST) properties for localized delivery, copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared with varying mole ratios of monomers. The copolymers showed LCST and gelation properties below body temperature in 0.1 N PBS solution of pH 7.4. The LCST and gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers was increased. The copolymers also showed time-dependent LCST and gelation properties in 0.1 N PBS solution of pH 7.4 owing to hydrolysis of HEMA-lactate. Hydrolysis of HEMA-lactate caused the polymers to be more hydrophilic, resulting in an increase in LCST and gelation temperature. All the polymers with about 6 mol % AAc exhibited LCST and gelation temperature above body temperature after complete hydrolysis of HEMA-lactate.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
EditorsC.T. Laurencin, E.A. Botchwey
Pages237-242
Number of pages6
Volume845
StatePublished - 2005
EventNanoscale Materials Science in Biology and Medicine - Boston, MA, United States
Duration: Nov 28 2004Dec 2 2004

Other

OtherNanoscale Materials Science in Biology and Medicine
CountryUnited States
CityBoston, MA
Period11/28/0412/2/04

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

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