Abstract
To develop a new class of in situ-forming, injectable, and biodegradable polymeric biomaterials based on time-dependent lower critical solution temperature (LCST) properties for localized delivery, copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared with varying mole ratios of monomers. The copolymers showed LCST and gelation properties below body temperature in 0.1 N PBS solution of pH 7.4. The LCST and gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers was increased. The copolymers also showed time-dependent LCST and gelation properties in 0.1 N PBS solution of pH 7.4 owing to hydrolysis of HEMA-lactate. Hydrolysis of HEMA-lactate caused the polymers to be more hydrophilic, resulting in an increase in LCST and gelation temperature. All the polymers with about 6 mol % AAc exhibited LCST and gelation temperature above body temperature after complete hydrolysis of HEMA-lactate.
| Original language | English (US) |
|---|---|
| Title of host publication | Materials Research Society Symposium Proceedings |
| Editors | C.T. Laurencin, E.A. Botchwey |
| Pages | 237-242 |
| Number of pages | 6 |
| Volume | 845 |
| State | Published - 2005 |
| Event | Nanoscale Materials Science in Biology and Medicine - Boston, MA, United States Duration: Nov 28 2004 → Dec 2 2004 |
Other
| Other | Nanoscale Materials Science in Biology and Medicine |
|---|---|
| Country/Territory | United States |
| City | Boston, MA |
| Period | 11/28/04 → 12/2/04 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials