Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits

Marianne M. Stanford, John W. Barrett, Philippe Alexandre Gilbert, Richard Bankert, Douglas McFadden

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.

Original languageEnglish (US)
Pages (from-to)12704-12708
Number of pages5
JournalJournal of Virology
Volume81
Issue number22
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Fingerprint

Myxoma virus
myxomatosis
interleukin-12
Interleukin-12
rabbits
Rabbits
Oncolytic Virotherapy
Lagomorpha
Vertebrates
Neoplasms
cytokines
vertebrates
Cytokines
Viruses
viruses
neoplasms
pathogens

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits. / Stanford, Marianne M.; Barrett, John W.; Gilbert, Philippe Alexandre; Bankert, Richard; McFadden, Douglas.

In: Journal of Virology, Vol. 81, No. 22, 01.11.2007, p. 12704-12708.

Research output: Contribution to journalArticle

Stanford, Marianne M. ; Barrett, John W. ; Gilbert, Philippe Alexandre ; Bankert, Richard ; McFadden, Douglas. / Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits. In: Journal of Virology. 2007 ; Vol. 81, No. 22. pp. 12704-12708.
@article{7be822761a39465397149298887ea962,
title = "Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits",
abstract = "Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.",
author = "Stanford, {Marianne M.} and Barrett, {John W.} and Gilbert, {Philippe Alexandre} and Richard Bankert and Douglas McFadden",
year = "2007",
month = "11",
day = "1",
doi = "10.1128/JVI.01483-07",
language = "English (US)",
volume = "81",
pages = "12704--12708",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "22",

}

TY - JOUR

T1 - Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits

AU - Stanford, Marianne M.

AU - Barrett, John W.

AU - Gilbert, Philippe Alexandre

AU - Bankert, Richard

AU - McFadden, Douglas

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.

AB - Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.

UR - http://www.scopus.com/inward/record.url?scp=36048971746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36048971746&partnerID=8YFLogxK

U2 - 10.1128/JVI.01483-07

DO - 10.1128/JVI.01483-07

M3 - Article

VL - 81

SP - 12704

EP - 12708

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 22

ER -