TY - JOUR
T1 - Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits
AU - Stanford, Marianne M.
AU - Barrett, John W.
AU - Gilbert, Philippe Alexandre
AU - Bankert, Richard
AU - McFadden, Grant
PY - 2007/11
Y1 - 2007/11
N2 - Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.
AB - Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxTL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.
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U2 - 10.1128/JVI.01483-07
DO - 10.1128/JVI.01483-07
M3 - Article
C2 - 17728229
AN - SCOPUS:36048971746
SN - 0022-538X
VL - 81
SP - 12704
EP - 12708
JO - Journal of virology
JF - Journal of virology
IS - 22
ER -