Molecular Genetics of Mycobacterium tuberculosis Pathogenesis

Josephine E. Clark-Curtiss, Shelley Haydel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Tuberculosis (TB) has afflicted humankind throughout history. Approximately one third of the world's population is currently infected with Mycobacterium tuberculosis and nearly two million people die of TB annually. Although much has been learned about the structure of the tubercle bacillus, the epidemiology of TB, the physiological and immunological responses of the host to infection, and the physiology of M. tuberculosis in laboratory broth cultures, much of the basic biology of M. tuberculosis in its natural setting (the infected human) remains to be elucidated. Within the past decade, there have been remarkable advances in the development of genetic and molecular biological tools with which to study M. tuberculosis. This review discusses the approaches that have been employed and the progress that has been made in discovering how M. tuberculosis has achieved its prowess as a successful pathogen.

Original languageEnglish (US)
Pages (from-to)517-549
Number of pages33
JournalAnnual Review of Microbiology
Volume57
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Mycobacterium tuberculosis
Molecular Biology
Tuberculosis
Bacillus
Epidemiology
History
Infection
Population

Keywords

  • Gene expression
  • Genomics
  • Mutagenesis
  • Proteomics
  • TB

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Molecular Genetics of Mycobacterium tuberculosis Pathogenesis. / Clark-Curtiss, Josephine E.; Haydel, Shelley.

In: Annual Review of Microbiology, Vol. 57, 2003, p. 517-549.

Research output: Contribution to journalArticle

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