Molecular genetic strategies for the development of anti-malarial vaccines

Jeffrey V. Ravetch, James Young, George Poste

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Malaria is one of the most important parasitic diseases of man. Efforts to reduce the prevalence and continued geographic spread of this disease by chemotherapy and spraying with insecticides to eradicate the mosquito vector have been hindered by the emergence of resistant strains of both parasite and vector. Recent advances in the identification and characterization of antigens associated with different stages of the parasite life cycle offer new opportunities for vaccination as a strategy for disease control. This article surveys current knowledge of the properties of candidate antigens for stage-specific malaria vaccines, describes progress in cloning the genes for these molecules and outlines current concepts regarding the feasibility of disease control by vaccination.

Original languageEnglish (US)
Pages (from-to)729-740
Number of pages12
JournalBio/Technology
Volume3
Issue number8
DOIs
StatePublished - Aug 1985

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ASJC Scopus subject areas

  • Biotechnology

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