TY - JOUR
T1 - Molecular control of the neural crest and peripheral nervous system development
AU - Newbern, Jason
PY - 2015
Y1 - 2015
N2 - A transient and unique population of multipotent stem cells, known as neural crest cells (NCCs), generate a bewildering array of cell types during vertebrate development. An attractive model among developmental biologists, the study of NCC biology has provided a wealth of knowledge regarding the cellular and molecular mechanisms important for embryogenesis. Studies in numerous species have defined how distinct phases of NCC specification, proliferation, migration, and survival contribute to the formation of multiple functionally distinct organ systems. NCC contributions to the peripheral nervous system (PNS) are well known. Critical developmental processes have been defined that provide outstanding models for understanding how extracellular stimuli, cell-cell interactions, and transcriptional networks cooperate to direct cellular diversification and PNS morphogenesis. Dissecting the complex extracellular and intracellular mechanisms that mediate the formation of the PNS from NCCs may have important therapeutic implications for neurocristopathies, neuropathies, and certain forms of cancer.
AB - A transient and unique population of multipotent stem cells, known as neural crest cells (NCCs), generate a bewildering array of cell types during vertebrate development. An attractive model among developmental biologists, the study of NCC biology has provided a wealth of knowledge regarding the cellular and molecular mechanisms important for embryogenesis. Studies in numerous species have defined how distinct phases of NCC specification, proliferation, migration, and survival contribute to the formation of multiple functionally distinct organ systems. NCC contributions to the peripheral nervous system (PNS) are well known. Critical developmental processes have been defined that provide outstanding models for understanding how extracellular stimuli, cell-cell interactions, and transcriptional networks cooperate to direct cellular diversification and PNS morphogenesis. Dissecting the complex extracellular and intracellular mechanisms that mediate the formation of the PNS from NCCs may have important therapeutic implications for neurocristopathies, neuropathies, and certain forms of cancer.
KW - Glia
KW - Nerve
KW - Schwann cell
KW - Sensory neuron
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=84922887919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922887919&partnerID=8YFLogxK
U2 - 10.1016/bs.ctdb.2014.11.007
DO - 10.1016/bs.ctdb.2014.11.007
M3 - Article
C2 - 25662262
AN - SCOPUS:84922887919
SN - 0070-2153
VL - 111
SP - 201
EP - 231
JO - Current Topics in Developmental Biology
JF - Current Topics in Developmental Biology
ER -