Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation

Clemens Heitzinger, Norbert J. Mauser, Christian Ringhofer, Yang Liu, Robert W. Dutton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We use the stochastic linearized Poisson-Boltzmann equation to model the fluctuations in nanowire field-effect biosensors due to changes in the orientation of the biomolecules. Different orientations of the biomolecules with respect to the sensor surface due to Brownian motion have different probabilities. The probabilities of the orientations are calculated from their electrostatic free energy. The structure considered here is a cross section through a rectangular silicon nanowire lying on a an oxide surface with a back-gate contact. The oxide surface of the nanowire is functionalized by biomolecules in an electrolyte with an electrode. Various combinations of PNA (peptide nucleic acid), single-stranded DNA, and double-stranded DNA are simulated to discuss the various states of a DNA sensor. A charge-transport models yields the current through the transducer that compares well with measurements.

Original languageEnglish (US)
Title of host publicationSISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices
DOIs
StatePublished - 2009
EventSISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices - San Diego, CA, United States
Duration: Sep 9 2009Sep 11 2009

Publication series

NameInternational Conference on Simulation of Semiconductor Processes and Devices, SISPAD

Other

OtherSISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices
CountryUnited States
CitySan Diego, CA
Period9/9/099/11/09

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Modeling and Simulation

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