Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation

Clemens Heitzinger; Norbert J. Mauser; Christian Ringhofer; Yang Liu; Robert W. Dutton

doi:10.1109/SISPAD.2009.5290244

Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation

Clemens Heitzinger, Norbert J. Mauser, Christian Ringhofer, Yang Liu, Robert W. Dutton

Mathematical and Statistical Sciences, School of (SoMSS)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We use the stochastic linearized Poisson-Boltzmann equation to model the fluctuations in nanowire field-effect biosensors due to changes in the orientation of the biomolecules. Different orientations of the biomolecules with respect to the sensor surface due to Brownian motion have different probabilities. The probabilities of the orientations are calculated from their electrostatic free energy. The structure considered here is a cross section through a rectangular silicon nanowire lying on a an oxide surface with a back-gate contact. The oxide surface of the nanowire is functionalized by biomolecules in an electrolyte with an electrode. Various combinations of PNA (peptide nucleic acid), single-stranded DNA, and double-stranded DNA are simulated to discuss the various states of a DNA sensor. A charge-transport models yields the current through the transducer that compares well with measurements.

Original language	English (US)
Title of host publication	SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices
DOIs	https://doi.org/10.1109/SISPAD.2009.5290244
State	Published - 2009
Event	SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices - San Diego, CA, United States Duration: Sep 9 2009 → Sep 11 2009

Publication series

Name	International Conference on Simulation of Semiconductor Processes and Devices, SISPAD

Other

Other	SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices
Country/Territory	United States
City	San Diego, CA
Period	9/9/09 → 9/11/09

ASJC Scopus subject areas

Electrical and Electronic Engineering
Computer Science Applications
Modeling and Simulation

Access to Document

10.1109/SISPAD.2009.5290244

Cite this

Heitzinger, C., Mauser, N. J., Ringhofer, C., Liu, Y., & Dutton, R. W. (2009). Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation. In SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices Article 5290244 (International Conference on Simulation of Semiconductor Processes and Devices, SISPAD). https://doi.org/10.1109/SISPAD.2009.5290244

Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation. / Heitzinger, Clemens; Mauser, Norbert J.; Ringhofer, Christian et al.
SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices. 2009. 5290244 (International Conference on Simulation of Semiconductor Processes and Devices, SISPAD).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Heitzinger, C, Mauser, NJ, Ringhofer, C, Liu, Y & Dutton, RW 2009, Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation. in SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices., 5290244, International Conference on Simulation of Semiconductor Processes and Devices, SISPAD, SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices, San Diego, CA, United States, 9/9/09. https://doi.org/10.1109/SISPAD.2009.5290244

Heitzinger C, Mauser NJ, Ringhofer C, Liu Y, Dutton RW. Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation. In SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices. 2009. 5290244. (International Conference on Simulation of Semiconductor Processes and Devices, SISPAD). doi: 10.1109/SISPAD.2009.5290244

Heitzinger, Clemens ; Mauser, Norbert J. ; Ringhofer, Christian et al. / Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation. SISPAD 2009 - 2009 International Conference on Simulation of Semiconductor Processes and Devices. 2009. (International Conference on Simulation of Semiconductor Processes and Devices, SISPAD).

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abstract = "We use the stochastic linearized Poisson-Boltzmann equation to model the fluctuations in nanowire field-effect biosensors due to changes in the orientation of the biomolecules. Different orientations of the biomolecules with respect to the sensor surface due to Brownian motion have different probabilities. The probabilities of the orientations are calculated from their electrostatic free energy. The structure considered here is a cross section through a rectangular silicon nanowire lying on a an oxide surface with a back-gate contact. The oxide surface of the nanowire is functionalized by biomolecules in an electrolyte with an electrode. Various combinations of PNA (peptide nucleic acid), single-stranded DNA, and double-stranded DNA are simulated to discuss the various states of a DNA sensor. A charge-transport models yields the current through the transducer that compares well with measurements.",

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AU - Liu, Yang

AU - Dutton, Robert W.

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AB - We use the stochastic linearized Poisson-Boltzmann equation to model the fluctuations in nanowire field-effect biosensors due to changes in the orientation of the biomolecules. Different orientations of the biomolecules with respect to the sensor surface due to Brownian motion have different probabilities. The probabilities of the orientations are calculated from their electrostatic free energy. The structure considered here is a cross section through a rectangular silicon nanowire lying on a an oxide surface with a back-gate contact. The oxide surface of the nanowire is functionalized by biomolecules in an electrolyte with an electrode. Various combinations of PNA (peptide nucleic acid), single-stranded DNA, and double-stranded DNA are simulated to discuss the various states of a DNA sensor. A charge-transport models yields the current through the transducer that compares well with measurements.

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Modeling and simulation of orientation-dependent fluctuations in nanowire field-effect biosensors using the stochastic linearized Poisson-Boltzmann equation

Abstract

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