Mixed fermentation for natural product drug discovery

Research output: Contribution to journalShort survey

115 Citations (Scopus)

Abstract

Natural products continue to play a major role in drug discovery and development. However, chemical redundancy is an ongoing problem. Genomic studies indicate that certain groups of bacteria and fungi have dozens of secondary metabolite pathways that are not expressed under standard laboratory growth conditions. One approach to more fully access the metabolic potential of cultivatable microbes is mixed fermentation, where the presence of neighboring microbes may induce secondary metabolite synthesis. Research to date indicates that mixed fermentation can result in increased antibiotic activity in crude extracts, increased yields of previously described metabolites, increased yields of previously undetected metabolites, analogues of known metabolites resulting from combined pathways and, importantly, induction of previously unexpressed pathways for bioactive constituents.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalApplied Microbiology and Biotechnology
Volume83
Issue number1
DOIs
StatePublished - May 1 2009

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Drug Discovery
Biological Products
Fermentation
Complex Mixtures
Fungi
Anti-Bacterial Agents
Bacteria
Growth
Research

Keywords

  • Co-culture
  • Mixed fermentation
  • Natural product
  • Secondary metabolite

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Mixed fermentation for natural product drug discovery. / Pettit, Robin.

In: Applied Microbiology and Biotechnology, Vol. 83, No. 1, 01.05.2009, p. 19-25.

Research output: Contribution to journalShort survey

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