Micro-and mesoscopic process interactions in protein coagulation

P. L. San Biagio, V. Martorana, A. Emanuele, Sara Vaiana, M. Manno, D. Bulone, M. B. Palma-Vittorelli, M. U. Palma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It has recently been recognized that pathological protein coagulation is responsible for lethal pathologies as diverse as amyloidosis, Alzheimer and TSE. Understanding the coagulation mechanisms is therefore stirring great interest. In previous studies we have shown that on profoundly different systems coagulation is the result of a strong interaction between two processes on different length scales (mesoscopic and microscopic). Here we report experiments on bovine serum albumin (BSA) showing that the overall mechanism is the result of at least 3 distinct and strongly intertwined processes, on both length scales: molecular conformational changes, solution demixing and intermolecular crosslinking. This mechanism involves the statistical mechanics of protein-solvent interaction, its relation to the protein's landscape of configurational free energy and to the solution's thermodynamic stability, and its relation to the topological problem of crosslink-percolation, responsible for coagulation.

Original languageEnglish (US)
Title of host publicationNuclear And Condensed Matter Physics
Subtitle of host publicationVI Regional Conference
PublisherAmerican Institute of Physics Inc.
Pages214-217
Number of pages4
Volume513
ISBN (Electronic)1563969297
DOIs
StatePublished - Apr 7 2000
Externally publishedYes
Event6th Regional Conference on Nuclear and Condensed Matter Physics - Palermo, Italy
Duration: Oct 14 1999Oct 15 1999

Other

Other6th Regional Conference on Nuclear and Condensed Matter Physics
CountryItaly
CityPalermo
Period10/14/9910/15/99

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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