Cocaine potently increases monoaminergic neurotransmission by inhibitingpresynaptic dopamine, norepinephrine, and serotonin transporters. However, a wealth ofevidence now exists that implicates an important role of the excitatory amino acidneurotransmitter glutamate and its receptors in the rewarding and reinforcing effects ofcocaine. Glutamatergic neurotransmission also appears to be involved in the extinction ofand relapse to cocaine-seeking.This chapter will review the clinical efficacy of medications with glutamatergicmechanisms of action for the treatment of cocaine addiction. Evidence from preclinicalanimal studies demonstrating potential efficacy of novel glutamatergic compounds for thetreatment of cocaine addiction will also be reviewed.
|Original language||English (US)|
|Title of host publication||Cocaine Abuse|
|Subtitle of host publication||Pharmacology, Treatment and Relapse Prevention|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||16|
|State||Published - Dec 1 2012|
ASJC Scopus subject areas