Mechanisms of the Improvement in Peak VO2 with Exercise Training in Heart Failure with Reduced or Preserved Ejection Fraction

Wesley J. Tucker, Cecilia C. Lijauco, Christopher M. Hearon, Siddhartha Angadi, Michael D. Nelson, Satyam Sarma, Shane Nanayakkara, André La Gerche, Mark J. Haykowsky

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Heart failure (HF) is a major health care burden associated with high morbidity and mortality. Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date suggests that the mechanism of this improvement appears to be related to underlying HF phenotype. The purpose of this review is to discuss the role of exercise training to improve VO2peak, and how the central and peripheral adaptations that mediate the improvements in exercise tolerance may be similar or differ by HF phenotype (HFrEF or HFpEF).

    Original languageEnglish (US)
    JournalHeart Lung and Circulation
    DOIs
    StateAccepted/In press - 2017

    Fingerprint

    Heart Failure
    Exercise
    Phenotype
    Oxygen
    Exercise Tolerance
    Dyspnea
    Skeletal Muscle
    Quality of Life
    Morbidity
    Delivery of Health Care
    Mortality

    Keywords

    • Aerobic capacity
    • Cardiac function
    • Exercise training
    • Heart failure
    • Skeletal muscle function
    • Vascular function

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Cardiology and Cardiovascular Medicine

    Cite this

    Mechanisms of the Improvement in Peak VO2 with Exercise Training in Heart Failure with Reduced or Preserved Ejection Fraction. / Tucker, Wesley J.; Lijauco, Cecilia C.; Hearon, Christopher M.; Angadi, Siddhartha; Nelson, Michael D.; Sarma, Satyam; Nanayakkara, Shane; La Gerche, André; Haykowsky, Mark J.

    In: Heart Lung and Circulation, 2017.

    Research output: Contribution to journalArticle

    Tucker, Wesley J. ; Lijauco, Cecilia C. ; Hearon, Christopher M. ; Angadi, Siddhartha ; Nelson, Michael D. ; Sarma, Satyam ; Nanayakkara, Shane ; La Gerche, André ; Haykowsky, Mark J. / Mechanisms of the Improvement in Peak VO2 with Exercise Training in Heart Failure with Reduced or Preserved Ejection Fraction. In: Heart Lung and Circulation. 2017.
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    abstract = "Heart failure (HF) is a major health care burden associated with high morbidity and mortality. Approximately 50{\%} of HF patients have reduced ejection fraction (HFrEF) while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date suggests that the mechanism of this improvement appears to be related to underlying HF phenotype. The purpose of this review is to discuss the role of exercise training to improve VO2peak, and how the central and peripheral adaptations that mediate the improvements in exercise tolerance may be similar or differ by HF phenotype (HFrEF or HFpEF).",
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    AU - Hearon, Christopher M.

    AU - Angadi, Siddhartha

    AU - Nelson, Michael D.

    AU - Sarma, Satyam

    AU - Nanayakkara, Shane

    AU - La Gerche, André

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