Mathematical models of the interrelated dynamics of hepatitis D and B

Aaron Packer, Jonathan Forde, Sarah Hews, Yang Kuang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The hepatitis delta virus (HDV) is a rarest form of viral hepatitis, but has the worst outcomes for patients. It is a subviral satellite dependent on coinfection with hepatitis B (HBV) to replicate within the host liver. To date, there has been little to no modeling effort for HDV. Deriving and analyzing such a mathematical model poses difficulty as it requires the inclusion of (HBV). Here we begin with a well-studied HBV model from the literature and expand it to incorporate HDV. We investigate two models, one with and one without infected hepatocyte replication. Additionally, we consider treatment by the drug lamivudine. Comparison of model simulations with experimental results of lamivudine treatment indicate that infected cell proliferation may play a significant role in chronic HDV infection. Our results also shed light on several questions surrounding HDV and illustrate the need for more data.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalMathematical Biosciences
Volume247
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • HBV
  • HDV
  • Hepatitis B
  • Hepatitis delta
  • Lamivudine
  • Mathematical model

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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